Immune-Related Four-lncRNA Signature for Patients with Cervical Cancer

Abstract EN

Cervical cancer (CC) is a common gynecological malignancy for which prognostic and therapeutic biomarkers are urgently needed.

The signature based on immune-related lncRNAs (IRLs) of CC has never been reported.

This study is aimed at establishing an IRL signature for patients with CC.

A cohort of 326 CC and 21 normal tissue samples with corresponding clinical information was included in this study.

Twenty-eight IRLs were collected according to the Pearson correlation analysis between the immune score and lncRNA expression (p<0.01).

Four IRLs (BZRAP1-AS1, EMX2OS, ZNF667-AS1, and CTC-429P9.1) with the most significant prognostic values (p<0.05) were identified which demonstrated an ability to stratify patients into the low-risk and high-risk groups by developing a risk score model.

It was observed that patients in the low-risk group showed longer overall survival (OS) than those in the high-risk group in the training set, valid set, and total set.

The area under the curve (AUC) of the receiver operating characteristic curve (ROC curve) for the four-IRL signature in predicting the one-, two-, and three-year survival rates was larger than 0.65.

In addition, the low-risk and high-risk groups displayed different immune statuses in GSEA.

These IRLs were also significantly correlated with immune cell infiltration.

Our results showed that the IRL signature had a prognostic value for CC.

Meanwhile, the specific mechanisms of the four IRLs in the development of CC were ascertained preliminarily.