Biological Pathways of Long-Term Visit-to-Visit Blood Pressure Variability in the American Population: Cardiovascular Health Study and Women’s Health Initiatives
المؤلفون المشاركون
Feingold, Eleanor
El-Faramawi, Mohammed
Orloff, Mohammed S.
Delongchamp, Robert
Wang, Yan
Thapa, Susan
Jin, Jing
Delhey, Leanna
Abouelenein, Saly
Zhang, Qing
Singh, Karan P.
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-19
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Studies reported a positive relationship between visit-to-visit blood pressure variability (VVBPV) and cardiovascular morbidity and mortality independently of the mean arterial blood pressure across clinical visits.
The literature is scarce on the genes and biological mechanisms that regulate long-term VVBPV.
We sought to identify biological pathways that regulate visit-to-visit blood pressure variability.
We used phenotypic and genotype data from the Women’s Health Initiatives and Cardiovascular Health Studies.
We defined VVBPV of systolic and diastolic blood pressure phenotypes as the standard deviation about the participant’s regression line with systolic and diastolic blood pressure regressed separately across visits.
We imputed missing genotypes and then conducted a genome-wide association analysis to identify genomic variants related to the VVBPV and detect biological pathways.
For systolic VVBPV, we identified a neurological pathway, the GABAergic pathway (P values = 1.1E − 2), and a vascular pathway, the RAP1 signaling pathway (P values = 5.8E − 2).
For diastolic VVBPV, the hippo signaling (P values = 4.1E − 2), CDO myogenesis (P values = 7.0E − 2), and O-glycosylation of TSR domain-containing protein pathways (P values = 9.0E − 2) were the significant pathways.
Future studies are warranted to validate these results.
Further understanding of the roles of the genes regulating the identified pathways will help researchers to improve future pharmacological interventions to treat VVBPV in clinical practice.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
El-Faramawi, Mohammed& Orloff, Mohammed S.& Delongchamp, Robert& Wang, Yan& Feingold, Eleanor& Thapa, Susan…[et al.]. 2020. Biological Pathways of Long-Term Visit-to-Visit Blood Pressure Variability in the American Population: Cardiovascular Health Study and Women’s Health Initiatives. BioMed Research International،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1133469
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
El-Faramawi, Mohammed…[et al.]. Biological Pathways of Long-Term Visit-to-Visit Blood Pressure Variability in the American Population: Cardiovascular Health Study and Women’s Health Initiatives. BioMed Research International No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1133469
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
El-Faramawi, Mohammed& Orloff, Mohammed S.& Delongchamp, Robert& Wang, Yan& Feingold, Eleanor& Thapa, Susan…[et al.]. Biological Pathways of Long-Term Visit-to-Visit Blood Pressure Variability in the American Population: Cardiovascular Health Study and Women’s Health Initiatives. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1133469
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1133469
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر