Biological Pathways of Long-Term Visit-to-Visit Blood Pressure Variability in the American Population: Cardiovascular Health Study and Women’s Health Initiatives
Joint Authors
Feingold, Eleanor
El-Faramawi, Mohammed
Orloff, Mohammed S.
Delongchamp, Robert
Wang, Yan
Thapa, Susan
Jin, Jing
Delhey, Leanna
Abouelenein, Saly
Zhang, Qing
Singh, Karan P.
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Studies reported a positive relationship between visit-to-visit blood pressure variability (VVBPV) and cardiovascular morbidity and mortality independently of the mean arterial blood pressure across clinical visits.
The literature is scarce on the genes and biological mechanisms that regulate long-term VVBPV.
We sought to identify biological pathways that regulate visit-to-visit blood pressure variability.
We used phenotypic and genotype data from the Women’s Health Initiatives and Cardiovascular Health Studies.
We defined VVBPV of systolic and diastolic blood pressure phenotypes as the standard deviation about the participant’s regression line with systolic and diastolic blood pressure regressed separately across visits.
We imputed missing genotypes and then conducted a genome-wide association analysis to identify genomic variants related to the VVBPV and detect biological pathways.
For systolic VVBPV, we identified a neurological pathway, the GABAergic pathway (P values = 1.1E − 2), and a vascular pathway, the RAP1 signaling pathway (P values = 5.8E − 2).
For diastolic VVBPV, the hippo signaling (P values = 4.1E − 2), CDO myogenesis (P values = 7.0E − 2), and O-glycosylation of TSR domain-containing protein pathways (P values = 9.0E − 2) were the significant pathways.
Future studies are warranted to validate these results.
Further understanding of the roles of the genes regulating the identified pathways will help researchers to improve future pharmacological interventions to treat VVBPV in clinical practice.
American Psychological Association (APA)
El-Faramawi, Mohammed& Orloff, Mohammed S.& Delongchamp, Robert& Wang, Yan& Feingold, Eleanor& Thapa, Susan…[et al.]. 2020. Biological Pathways of Long-Term Visit-to-Visit Blood Pressure Variability in the American Population: Cardiovascular Health Study and Women’s Health Initiatives. BioMed Research International،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1133469
Modern Language Association (MLA)
El-Faramawi, Mohammed…[et al.]. Biological Pathways of Long-Term Visit-to-Visit Blood Pressure Variability in the American Population: Cardiovascular Health Study and Women’s Health Initiatives. BioMed Research International No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1133469
American Medical Association (AMA)
El-Faramawi, Mohammed& Orloff, Mohammed S.& Delongchamp, Robert& Wang, Yan& Feingold, Eleanor& Thapa, Susan…[et al.]. Biological Pathways of Long-Term Visit-to-Visit Blood Pressure Variability in the American Population: Cardiovascular Health Study and Women’s Health Initiatives. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1133469
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1133469