Systematic Elucidation of the Mechanism of Quercetin against Gastric Cancer via Network Pharmacology Approach
المؤلفون المشاركون
Zhu, Jia-Jie
Yang, Liangjun
Hu, Zhipeng
Liang, Qiting
Zhou, Hengli
Li, Jiali
Fan, Xiangzhen
Zhao, Ziming
Pan, Huafeng
Fei, Baoying
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-09-03
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
This study was aimed at elucidating the potential mechanisms of quercetin in the treatment of gastric cancer (GC).
A network pharmacology approach was used to analyze the targets and pathways of quercetin in treating GC.
The predicted targets of quercetin against GC were obtained through database mining, and the correlation of these targets with GC was analyzed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses.
Next, the protein-protein interaction (PPI) network was constructed, and overall survival (OS) analysis of hub targets was performed using the Kaplan–Meier Plotter online tool.
Finally, the mechanism was further analyzed via molecular docking of quercetin with the hub targets.
Thirty-six quercetin-related genes were identified, 15 of which overlapped with GC-related targets.
These targets were further mapped to 319 GO biological process terms and 10 remarkable pathways.
In the PPI network analysis, six hub targets were identified, including AKT1, EGFR, SRC, IGF1R, PTK2, and KDR.
The high expression of these targets was related to poor OS in GC patients.
Molecular docking analysis confirmed that quercetin can bind to these hub targets.
In conclusion, this study provided a novel approach to reveal the therapeutic mechanisms of quercetin on GC, which will ease the future clinical application of quercetin in the treatment of GC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Liangjun& Hu, Zhipeng& Zhu, Jia-Jie& Liang, Qiting& Zhou, Hengli& Li, Jiali…[et al.]. 2020. Systematic Elucidation of the Mechanism of Quercetin against Gastric Cancer via Network Pharmacology Approach. BioMed Research International،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1133488
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Liangjun…[et al.]. Systematic Elucidation of the Mechanism of Quercetin against Gastric Cancer via Network Pharmacology Approach. BioMed Research International No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1133488
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Liangjun& Hu, Zhipeng& Zhu, Jia-Jie& Liang, Qiting& Zhou, Hengli& Li, Jiali…[et al.]. Systematic Elucidation of the Mechanism of Quercetin against Gastric Cancer via Network Pharmacology Approach. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1133488
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1133488
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر