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Systematic Elucidation of the Mechanism of Quercetin against Gastric Cancer via Network Pharmacology Approach
Joint Authors
Zhu, Jia-Jie
Yang, Liangjun
Hu, Zhipeng
Liang, Qiting
Zhou, Hengli
Li, Jiali
Fan, Xiangzhen
Zhao, Ziming
Pan, Huafeng
Fei, Baoying
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-03
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
This study was aimed at elucidating the potential mechanisms of quercetin in the treatment of gastric cancer (GC).
A network pharmacology approach was used to analyze the targets and pathways of quercetin in treating GC.
The predicted targets of quercetin against GC were obtained through database mining, and the correlation of these targets with GC was analyzed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses.
Next, the protein-protein interaction (PPI) network was constructed, and overall survival (OS) analysis of hub targets was performed using the Kaplan–Meier Plotter online tool.
Finally, the mechanism was further analyzed via molecular docking of quercetin with the hub targets.
Thirty-six quercetin-related genes were identified, 15 of which overlapped with GC-related targets.
These targets were further mapped to 319 GO biological process terms and 10 remarkable pathways.
In the PPI network analysis, six hub targets were identified, including AKT1, EGFR, SRC, IGF1R, PTK2, and KDR.
The high expression of these targets was related to poor OS in GC patients.
Molecular docking analysis confirmed that quercetin can bind to these hub targets.
In conclusion, this study provided a novel approach to reveal the therapeutic mechanisms of quercetin on GC, which will ease the future clinical application of quercetin in the treatment of GC.
American Psychological Association (APA)
Yang, Liangjun& Hu, Zhipeng& Zhu, Jia-Jie& Liang, Qiting& Zhou, Hengli& Li, Jiali…[et al.]. 2020. Systematic Elucidation of the Mechanism of Quercetin against Gastric Cancer via Network Pharmacology Approach. BioMed Research International،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1133488
Modern Language Association (MLA)
Yang, Liangjun…[et al.]. Systematic Elucidation of the Mechanism of Quercetin against Gastric Cancer via Network Pharmacology Approach. BioMed Research International No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1133488
American Medical Association (AMA)
Yang, Liangjun& Hu, Zhipeng& Zhu, Jia-Jie& Liang, Qiting& Zhou, Hengli& Li, Jiali…[et al.]. Systematic Elucidation of the Mechanism of Quercetin against Gastric Cancer via Network Pharmacology Approach. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1133488
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1133488