SOX1 and PAX1 Are Hypermethylated in Cervical Adenocarcinoma and Associated with Better Prognosis
المؤلفون المشاركون
Zhao, Zitong
Zhang, Xiaoye
Zhao, Xueheng
Cai, Jingting
Wu, Na-Yi Yuan
Wang, Jing
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-12-08
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
The increased risk and poor survival outcome of cervical adenocarcinoma (CAC) demand for effective early diagnostic biomarkers that can predict the disease progression and outcome.
The purpose of this study was to investigate the value of methylation status of SOX1 and PAX1 in the detection and prognosis of CAC.
Methods.
We performed a quantitative methylation-specific polymerase chain reaction in 205 cervical paraffin-embedded specimens (175 CACs, 30 noncancer cervical tissues).
Overall and progression-free survival (OS and PFS, respectively) rates were calculated and compared using the Kaplan-Meier method.
The prognostic value of SOX1m and PAX1m on CAC patients was assessed by the Cox regression model.
A mathematical formula combining SOX1m, PAX1m, and age was constructed for survival prediction.
Results.
The methylation status of SOX1 and PAX1 was higher in CAC tissues than in noncancer cervical tissues.
In addition, SOX1m-positive CAC patients showed a higher 5-year OS rate than SOX1m-negative patients.
In CAC patients with smaller tumor size (<4 cm), the PAX1m-positive group showed a higher 5-year PFS rate than the PAX1m-negative group.
In the algorithm combining SOX1m, PAX1m, and age, the low-risk group showed a better 5-year OS and PFS rate than the high-risk group.
Conclusion.
SOX1 and PAX1 methylation levels are higher in CAC than in normal cervical tissues and are potential biomarkers for monitoring CAC prognosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhao, Zitong& Zhang, Xiaoye& Zhao, Xueheng& Cai, Jingting& Wu, Na-Yi Yuan& Wang, Jing. 2020. SOX1 and PAX1 Are Hypermethylated in Cervical Adenocarcinoma and Associated with Better Prognosis. BioMed Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1133591
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhao, Zitong…[et al.]. SOX1 and PAX1 Are Hypermethylated in Cervical Adenocarcinoma and Associated with Better Prognosis. BioMed Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1133591
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhao, Zitong& Zhang, Xiaoye& Zhao, Xueheng& Cai, Jingting& Wu, Na-Yi Yuan& Wang, Jing. SOX1 and PAX1 Are Hypermethylated in Cervical Adenocarcinoma and Associated with Better Prognosis. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1133591
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1133591
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر