SOX1 and PAX1 Are Hypermethylated in Cervical Adenocarcinoma and Associated with Better Prognosis
Joint Authors
Zhao, Zitong
Zhang, Xiaoye
Zhao, Xueheng
Cai, Jingting
Wu, Na-Yi Yuan
Wang, Jing
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
The increased risk and poor survival outcome of cervical adenocarcinoma (CAC) demand for effective early diagnostic biomarkers that can predict the disease progression and outcome.
The purpose of this study was to investigate the value of methylation status of SOX1 and PAX1 in the detection and prognosis of CAC.
Methods.
We performed a quantitative methylation-specific polymerase chain reaction in 205 cervical paraffin-embedded specimens (175 CACs, 30 noncancer cervical tissues).
Overall and progression-free survival (OS and PFS, respectively) rates were calculated and compared using the Kaplan-Meier method.
The prognostic value of SOX1m and PAX1m on CAC patients was assessed by the Cox regression model.
A mathematical formula combining SOX1m, PAX1m, and age was constructed for survival prediction.
Results.
The methylation status of SOX1 and PAX1 was higher in CAC tissues than in noncancer cervical tissues.
In addition, SOX1m-positive CAC patients showed a higher 5-year OS rate than SOX1m-negative patients.
In CAC patients with smaller tumor size (<4 cm), the PAX1m-positive group showed a higher 5-year PFS rate than the PAX1m-negative group.
In the algorithm combining SOX1m, PAX1m, and age, the low-risk group showed a better 5-year OS and PFS rate than the high-risk group.
Conclusion.
SOX1 and PAX1 methylation levels are higher in CAC than in normal cervical tissues and are potential biomarkers for monitoring CAC prognosis.
American Psychological Association (APA)
Zhao, Zitong& Zhang, Xiaoye& Zhao, Xueheng& Cai, Jingting& Wu, Na-Yi Yuan& Wang, Jing. 2020. SOX1 and PAX1 Are Hypermethylated in Cervical Adenocarcinoma and Associated with Better Prognosis. BioMed Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1133591
Modern Language Association (MLA)
Zhao, Zitong…[et al.]. SOX1 and PAX1 Are Hypermethylated in Cervical Adenocarcinoma and Associated with Better Prognosis. BioMed Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1133591
American Medical Association (AMA)
Zhao, Zitong& Zhang, Xiaoye& Zhao, Xueheng& Cai, Jingting& Wu, Na-Yi Yuan& Wang, Jing. SOX1 and PAX1 Are Hypermethylated in Cervical Adenocarcinoma and Associated with Better Prognosis. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1133591
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1133591