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Effect of Glycine, Pyruvate, and Resveratrol on the Regeneration Process of Postischemic Intestinal Mucosa
المؤلفون المشاركون
Brencher, Lisa
Petrat, Frank
Stych, Katrin
Hamburger, Tim
Kirsch, Michael
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-10-19
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Intestinal ischemia is often caused by a malperfusion of the upper mesenteric artery.
Since the intestinal mucosa is one of the most rapidly proliferating organs in human body, this tissue can partly regenerate itself after the onset of ischemia and reperfusion (I/R).
Therefore, we investigated whether glycine, sodium pyruvate, and resveratrol can either support or potentially harm regeneration when applied therapeutically after reperfusion injury.
Methods.
I/R of the small intestine was initiated by occluding and reopening the upper mesenteric artery in rats.
After 60 min of ischemia and 300 min of reperfusion, glycine, sodium pyruvate, or resveratrol was administered intravenously.
Small intestine regeneration was analyzed regarding tissue damage, activity of saccharase, and Ki-67 positive cells.
Additionally, systemic parameters and metabolic ones were obtained at selected periods.
Results.
Resveratrol failed in improving the outcome after I/R, while glycine showed a partial beneficial effect.
Sodium pyruvate ameliorated metabolic acidosis, diminished histopathologic tissue injury, and increased cell proliferation in the small intestine.
Conclusion.
While glycine could improve in part regeneration but not proliferation, sodium pyruvate seems to be a possible therapeutic agent to facilitate proliferation and to support mucosal regeneration after I/R injury to the small intestine.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Brencher, Lisa& Petrat, Frank& Stych, Katrin& Hamburger, Tim& Kirsch, Michael. 2017. Effect of Glycine, Pyruvate, and Resveratrol on the Regeneration Process of Postischemic Intestinal Mucosa. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1133659
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Brencher, Lisa…[et al.]. Effect of Glycine, Pyruvate, and Resveratrol on the Regeneration Process of Postischemic Intestinal Mucosa. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1133659
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Brencher, Lisa& Petrat, Frank& Stych, Katrin& Hamburger, Tim& Kirsch, Michael. Effect of Glycine, Pyruvate, and Resveratrol on the Regeneration Process of Postischemic Intestinal Mucosa. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1133659
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1133659
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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