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Effect of Glycine, Pyruvate, and Resveratrol on the Regeneration Process of Postischemic Intestinal Mucosa
Joint Authors
Brencher, Lisa
Petrat, Frank
Stych, Katrin
Hamburger, Tim
Kirsch, Michael
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Intestinal ischemia is often caused by a malperfusion of the upper mesenteric artery.
Since the intestinal mucosa is one of the most rapidly proliferating organs in human body, this tissue can partly regenerate itself after the onset of ischemia and reperfusion (I/R).
Therefore, we investigated whether glycine, sodium pyruvate, and resveratrol can either support or potentially harm regeneration when applied therapeutically after reperfusion injury.
Methods.
I/R of the small intestine was initiated by occluding and reopening the upper mesenteric artery in rats.
After 60 min of ischemia and 300 min of reperfusion, glycine, sodium pyruvate, or resveratrol was administered intravenously.
Small intestine regeneration was analyzed regarding tissue damage, activity of saccharase, and Ki-67 positive cells.
Additionally, systemic parameters and metabolic ones were obtained at selected periods.
Results.
Resveratrol failed in improving the outcome after I/R, while glycine showed a partial beneficial effect.
Sodium pyruvate ameliorated metabolic acidosis, diminished histopathologic tissue injury, and increased cell proliferation in the small intestine.
Conclusion.
While glycine could improve in part regeneration but not proliferation, sodium pyruvate seems to be a possible therapeutic agent to facilitate proliferation and to support mucosal regeneration after I/R injury to the small intestine.
American Psychological Association (APA)
Brencher, Lisa& Petrat, Frank& Stych, Katrin& Hamburger, Tim& Kirsch, Michael. 2017. Effect of Glycine, Pyruvate, and Resveratrol on the Regeneration Process of Postischemic Intestinal Mucosa. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1133659
Modern Language Association (MLA)
Brencher, Lisa…[et al.]. Effect of Glycine, Pyruvate, and Resveratrol on the Regeneration Process of Postischemic Intestinal Mucosa. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1133659
American Medical Association (AMA)
Brencher, Lisa& Petrat, Frank& Stych, Katrin& Hamburger, Tim& Kirsch, Michael. Effect of Glycine, Pyruvate, and Resveratrol on the Regeneration Process of Postischemic Intestinal Mucosa. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1133659
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1133659