Racial Differences in Esophageal Squamous Cell Carcinoma: Incidence and Molecular Features
المؤلفون المشاركون
Ding, Guohui
Li, Hong
Chen, Shirui
Zhou, Kai
Yang, Liguang
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-14
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The incidence and histological type of esophageal cancer are highly variable depending on geographic location and race/ethnicity.
Here we want to determine if racial difference exists in the molecular features of esophageal cancer.
We firstly confirmed that the incidence rate of esophagus adenocarcinoma (EA) was higher in Whites than in Asians and Blacks, while the incidence of esophageal squamous cell carcinoma (ESCC) was highest in Asians.
Then we compared the genome-wide somatic mutations, methylation, and gene expression to identify differential genes by race.
The mutation frequencies of some genes in the same pathway showed opposite difference between Asian and White patients, but their functional effects to the pathway may be consistent.
The global patterns of methylation and expression were similar, which reflected the common characteristics of ESCC tumors from different populations.
A small number of genes had significant differences between Asians and Whites.
More interesting, the racial differences of COL11A1 were consistent across multiple molecular levels, with higher mutation frequency, higher methylation, and lower expression in White patients.
This indicated that COL11A1 might play important roles in ESCC, especially in White population.
Additional studies are needed to further explore their functions in esophageal cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Shirui& Zhou, Kai& Yang, Liguang& Ding, Guohui& Li, Hong. 2017. Racial Differences in Esophageal Squamous Cell Carcinoma: Incidence and Molecular Features. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1133699
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Shirui…[et al.]. Racial Differences in Esophageal Squamous Cell Carcinoma: Incidence and Molecular Features. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1133699
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Shirui& Zhou, Kai& Yang, Liguang& Ding, Guohui& Li, Hong. Racial Differences in Esophageal Squamous Cell Carcinoma: Incidence and Molecular Features. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1133699
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1133699
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر