Racial Differences in Esophageal Squamous Cell Carcinoma: Incidence and Molecular Features
Joint Authors
Ding, Guohui
Li, Hong
Chen, Shirui
Zhou, Kai
Yang, Liguang
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The incidence and histological type of esophageal cancer are highly variable depending on geographic location and race/ethnicity.
Here we want to determine if racial difference exists in the molecular features of esophageal cancer.
We firstly confirmed that the incidence rate of esophagus adenocarcinoma (EA) was higher in Whites than in Asians and Blacks, while the incidence of esophageal squamous cell carcinoma (ESCC) was highest in Asians.
Then we compared the genome-wide somatic mutations, methylation, and gene expression to identify differential genes by race.
The mutation frequencies of some genes in the same pathway showed opposite difference between Asian and White patients, but their functional effects to the pathway may be consistent.
The global patterns of methylation and expression were similar, which reflected the common characteristics of ESCC tumors from different populations.
A small number of genes had significant differences between Asians and Whites.
More interesting, the racial differences of COL11A1 were consistent across multiple molecular levels, with higher mutation frequency, higher methylation, and lower expression in White patients.
This indicated that COL11A1 might play important roles in ESCC, especially in White population.
Additional studies are needed to further explore their functions in esophageal cancer.
American Psychological Association (APA)
Chen, Shirui& Zhou, Kai& Yang, Liguang& Ding, Guohui& Li, Hong. 2017. Racial Differences in Esophageal Squamous Cell Carcinoma: Incidence and Molecular Features. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1133699
Modern Language Association (MLA)
Chen, Shirui…[et al.]. Racial Differences in Esophageal Squamous Cell Carcinoma: Incidence and Molecular Features. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1133699
American Medical Association (AMA)
Chen, Shirui& Zhou, Kai& Yang, Liguang& Ding, Guohui& Li, Hong. Racial Differences in Esophageal Squamous Cell Carcinoma: Incidence and Molecular Features. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1133699
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1133699