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Prognostic Value and Immune Infiltrates of ABCA8 and FABP4 in Stomach Adenocarcinoma
المؤلفون المشاركون
Guo, Ya
Wang, Zhong Wei
Su, Wang Hui
Chen, Jing
Wang, Ya Li
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-06-28
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Background.
Stomach adenocarcinoma (STAD) is a common malignancy worldwide with poor prognosis.
Therefore, it is important to identify a valuable prognostic biomarker for STAD.
The aim of present study was to identify novel prognostic biomarkers for STAD and evaluate the potential role of hub genes in STAD.
Methods.
Gene Expression Profiling Interactive Analysis (GEPIA) and Cancer RNA-Seq Nexus were performed to identify differentially expressed genes (DEGs).
Subsequently, hub genes were selected by a Venn diagram, and the expression of key genes was confirmed by UALCAN database.
Furthermore, survival analysis of these hub genes was performed using Oncolnc and Human Protein Atlas (HPA) database.
Gene alteration status of hub genes was assessed by cBioPortal.
Finally, we investigated the association between hub genes and immune cell infiltration in STAD through the Tumor Immune Estimation Resource (TIMER) and GEPIA database.
Results.
Three common hub genes were obtained, including 2 downregulated DEGs (ABCA8 and FABP4) and one upregulated DEG (SLC52A3).
Furthermore, increased expression of ABCA8 and FABP4 and decreased expression of SLC52A3 were correlated with poor prognosis.
Meanwhile, three hub genes showed genetic alterations in various datasets of STAD.
Finally, our results showed that ABCA8 and FABP4 displayed a positive correlation with immune infiltration, especially in M2 macrophages.
Conclusions.
The results of this study suggest that ABCA8 and FABP4 may be used as prognostic biomarkers and correlated with immune infiltration in STAD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Guo, Ya& Wang, Zhong Wei& Su, Wang Hui& Chen, Jing& Wang, Ya Li. 2020. Prognostic Value and Immune Infiltrates of ABCA8 and FABP4 in Stomach Adenocarcinoma. BioMed Research International،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1133724
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Guo, Ya…[et al.]. Prognostic Value and Immune Infiltrates of ABCA8 and FABP4 in Stomach Adenocarcinoma. BioMed Research International No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1133724
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Guo, Ya& Wang, Zhong Wei& Su, Wang Hui& Chen, Jing& Wang, Ya Li. Prognostic Value and Immune Infiltrates of ABCA8 and FABP4 in Stomach Adenocarcinoma. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1133724
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1133724
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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