Prognostic Value and Immune Infiltrates of ABCA8 and FABP4 in Stomach Adenocarcinoma
Joint Authors
Guo, Ya
Wang, Zhong Wei
Su, Wang Hui
Chen, Jing
Wang, Ya Li
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-28
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background.
Stomach adenocarcinoma (STAD) is a common malignancy worldwide with poor prognosis.
Therefore, it is important to identify a valuable prognostic biomarker for STAD.
The aim of present study was to identify novel prognostic biomarkers for STAD and evaluate the potential role of hub genes in STAD.
Methods.
Gene Expression Profiling Interactive Analysis (GEPIA) and Cancer RNA-Seq Nexus were performed to identify differentially expressed genes (DEGs).
Subsequently, hub genes were selected by a Venn diagram, and the expression of key genes was confirmed by UALCAN database.
Furthermore, survival analysis of these hub genes was performed using Oncolnc and Human Protein Atlas (HPA) database.
Gene alteration status of hub genes was assessed by cBioPortal.
Finally, we investigated the association between hub genes and immune cell infiltration in STAD through the Tumor Immune Estimation Resource (TIMER) and GEPIA database.
Results.
Three common hub genes were obtained, including 2 downregulated DEGs (ABCA8 and FABP4) and one upregulated DEG (SLC52A3).
Furthermore, increased expression of ABCA8 and FABP4 and decreased expression of SLC52A3 were correlated with poor prognosis.
Meanwhile, three hub genes showed genetic alterations in various datasets of STAD.
Finally, our results showed that ABCA8 and FABP4 displayed a positive correlation with immune infiltration, especially in M2 macrophages.
Conclusions.
The results of this study suggest that ABCA8 and FABP4 may be used as prognostic biomarkers and correlated with immune infiltration in STAD.
American Psychological Association (APA)
Guo, Ya& Wang, Zhong Wei& Su, Wang Hui& Chen, Jing& Wang, Ya Li. 2020. Prognostic Value and Immune Infiltrates of ABCA8 and FABP4 in Stomach Adenocarcinoma. BioMed Research International،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1133724
Modern Language Association (MLA)
Guo, Ya…[et al.]. Prognostic Value and Immune Infiltrates of ABCA8 and FABP4 in Stomach Adenocarcinoma. BioMed Research International No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1133724
American Medical Association (AMA)
Guo, Ya& Wang, Zhong Wei& Su, Wang Hui& Chen, Jing& Wang, Ya Li. Prognostic Value and Immune Infiltrates of ABCA8 and FABP4 in Stomach Adenocarcinoma. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1133724
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1133724