Increased ERp57 Expression in HBV-Related Hepatocellular Carcinoma: Possible Correlation and Prognosis
المؤلفون المشاركون
Tang, Hong
Liu, Miao
Du, Lingyao
He, Zhiliang
Yan, Libo
Shi, Ying
Shang, Jin
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-08
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Aim.
ERp57 is involved in virus induced endoplasmic reticulum stress (ERS) and plays an important role in tumorigenesis.
This study aimed to find whether HBV infection altered ERp57 expression and whether ERp57 regulation was involved in hepatitis B virus-related hepatocellular carcinoma (HBV-HCC) genesis.
Materials and Methods.
HBV-HCC tissues, chronic hepatitis B (CHB) liver tissues, and normal liver tissues were acquired.
ERp57 expressions in these tissues were detected through immunohistochemistry (IHC).
And ERp57 expression in liver cell line L02, HBV replicative liver cell line L02-pHBV4.1, and HCC cell lines were detected through western blot for verification.
Then medical data on patients providing HCC tissues were collected and analyzed along with ERp57 expression.
Results.
Higher ERp57 expression was found in HCC and CHB tissues (p<0.001).
And HCC cell lines and L02-pHBV4.1 presented higher ERp57 expression as well.
In patients, ERp57 expression showed significant differences between death and survival groups (p=0.037).
And cumulative survival in patients with higher ERp57 (score ⩾ 8.75) is significantly lower (p=0.009).
Conclusion.
Our study found increased expression of ERp57 in HBV-HCC.
Such altered expression could be related to HBV infection and high ERp57 expression may lead to poor prognosis of HBV-HCC patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Miao& Du, Lingyao& He, Zhiliang& Yan, Libo& Shi, Ying& Shang, Jin…[et al.]. 2017. Increased ERp57 Expression in HBV-Related Hepatocellular Carcinoma: Possible Correlation and Prognosis. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1133738
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Miao…[et al.]. Increased ERp57 Expression in HBV-Related Hepatocellular Carcinoma: Possible Correlation and Prognosis. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1133738
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Miao& Du, Lingyao& He, Zhiliang& Yan, Libo& Shi, Ying& Shang, Jin…[et al.]. Increased ERp57 Expression in HBV-Related Hepatocellular Carcinoma: Possible Correlation and Prognosis. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1133738
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1133738
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر