Increased ERp57 Expression in HBV-Related Hepatocellular Carcinoma: Possible Correlation and Prognosis
Joint Authors
Tang, Hong
Liu, Miao
Du, Lingyao
He, Zhiliang
Yan, Libo
Shi, Ying
Shang, Jin
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aim.
ERp57 is involved in virus induced endoplasmic reticulum stress (ERS) and plays an important role in tumorigenesis.
This study aimed to find whether HBV infection altered ERp57 expression and whether ERp57 regulation was involved in hepatitis B virus-related hepatocellular carcinoma (HBV-HCC) genesis.
Materials and Methods.
HBV-HCC tissues, chronic hepatitis B (CHB) liver tissues, and normal liver tissues were acquired.
ERp57 expressions in these tissues were detected through immunohistochemistry (IHC).
And ERp57 expression in liver cell line L02, HBV replicative liver cell line L02-pHBV4.1, and HCC cell lines were detected through western blot for verification.
Then medical data on patients providing HCC tissues were collected and analyzed along with ERp57 expression.
Results.
Higher ERp57 expression was found in HCC and CHB tissues (p<0.001).
And HCC cell lines and L02-pHBV4.1 presented higher ERp57 expression as well.
In patients, ERp57 expression showed significant differences between death and survival groups (p=0.037).
And cumulative survival in patients with higher ERp57 (score ⩾ 8.75) is significantly lower (p=0.009).
Conclusion.
Our study found increased expression of ERp57 in HBV-HCC.
Such altered expression could be related to HBV infection and high ERp57 expression may lead to poor prognosis of HBV-HCC patients.
American Psychological Association (APA)
Liu, Miao& Du, Lingyao& He, Zhiliang& Yan, Libo& Shi, Ying& Shang, Jin…[et al.]. 2017. Increased ERp57 Expression in HBV-Related Hepatocellular Carcinoma: Possible Correlation and Prognosis. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1133738
Modern Language Association (MLA)
Liu, Miao…[et al.]. Increased ERp57 Expression in HBV-Related Hepatocellular Carcinoma: Possible Correlation and Prognosis. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1133738
American Medical Association (AMA)
Liu, Miao& Du, Lingyao& He, Zhiliang& Yan, Libo& Shi, Ying& Shang, Jin…[et al.]. Increased ERp57 Expression in HBV-Related Hepatocellular Carcinoma: Possible Correlation and Prognosis. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1133738
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1133738