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Full-Length TrkB Variant in NSCLC Is Associated with Brain Metastasis
المؤلفون المشاركون
Vecchione, Andrea
Mancini, Rita
Ricci, Alberto
Giordano, Marco
Lombardi, Mariangela
D'Ascanio, Michela
Scarpino, Stefania
Scozzi, Davide
Raj, Enrico Rathina
Cardillo, Giuseppe
Cardaci, Vittorio
Innammorato, Marta
Costarelli, Leopoldo
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-18
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Despite remarkable therapeutic advances have been made in the last few decades, non-small cell lung cancer (NSCLC) is still one of the leading causes of death worldwide.
Brain metastases are a common complication of a wide range of human malignancies and in particular NSCLC.
Brain-derived neurotrophic factor (BDNF), binding its high-affinity tyrosine kinase B receptor, has been shown to promote cancer progression and metastasis.
We hereby investigated the expression of the BDNF and its TrkB receptor in its full-length and truncated isoform T1, in samples from primary adenocarcinomas (ADKs) of the lung and in their metastasis to evaluate if their expression was related to preferential tumor entry into the central nervous system (CNS).
By immunohistochemistry, 80% of the ADKs that metastasize to central nervous system expressed TrkB receptor compared to 33% expressing of ADKs without CNS metastasis.
Moreover, ADKs with CNS metastasis showed an elevated expression of the full-length TrkB receptor.
The TrkB receptor FL/T1 ratio was statistically higher in primary ADKs with brain metastasis compared to ADKs without brain metastasis.
Our data indicate that TrkB full-length isoform expression in primary ADK cells may be associated with higher risk to develop brain metastasis.
Therefore, TrkB receptor may possess prognostic and therapeutic implications in lung ADK.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lombardi, Mariangela& D'Ascanio, Michela& Scarpino, Stefania& Scozzi, Davide& Giordano, Marco& Costarelli, Leopoldo…[et al.]. 2020. Full-Length TrkB Variant in NSCLC Is Associated with Brain Metastasis. BioMed Research International،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1133774
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lombardi, Mariangela…[et al.]. Full-Length TrkB Variant in NSCLC Is Associated with Brain Metastasis. BioMed Research International No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1133774
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lombardi, Mariangela& D'Ascanio, Michela& Scarpino, Stefania& Scozzi, Davide& Giordano, Marco& Costarelli, Leopoldo…[et al.]. Full-Length TrkB Variant in NSCLC Is Associated with Brain Metastasis. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1133774
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1133774
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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