Full-Length TrkB Variant in NSCLC Is Associated with Brain Metastasis
Joint Authors
Vecchione, Andrea
Mancini, Rita
Ricci, Alberto
Giordano, Marco
Lombardi, Mariangela
D'Ascanio, Michela
Scarpino, Stefania
Scozzi, Davide
Raj, Enrico Rathina
Cardillo, Giuseppe
Cardaci, Vittorio
Innammorato, Marta
Costarelli, Leopoldo
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Despite remarkable therapeutic advances have been made in the last few decades, non-small cell lung cancer (NSCLC) is still one of the leading causes of death worldwide.
Brain metastases are a common complication of a wide range of human malignancies and in particular NSCLC.
Brain-derived neurotrophic factor (BDNF), binding its high-affinity tyrosine kinase B receptor, has been shown to promote cancer progression and metastasis.
We hereby investigated the expression of the BDNF and its TrkB receptor in its full-length and truncated isoform T1, in samples from primary adenocarcinomas (ADKs) of the lung and in their metastasis to evaluate if their expression was related to preferential tumor entry into the central nervous system (CNS).
By immunohistochemistry, 80% of the ADKs that metastasize to central nervous system expressed TrkB receptor compared to 33% expressing of ADKs without CNS metastasis.
Moreover, ADKs with CNS metastasis showed an elevated expression of the full-length TrkB receptor.
The TrkB receptor FL/T1 ratio was statistically higher in primary ADKs with brain metastasis compared to ADKs without brain metastasis.
Our data indicate that TrkB full-length isoform expression in primary ADK cells may be associated with higher risk to develop brain metastasis.
Therefore, TrkB receptor may possess prognostic and therapeutic implications in lung ADK.
American Psychological Association (APA)
Lombardi, Mariangela& D'Ascanio, Michela& Scarpino, Stefania& Scozzi, Davide& Giordano, Marco& Costarelli, Leopoldo…[et al.]. 2020. Full-Length TrkB Variant in NSCLC Is Associated with Brain Metastasis. BioMed Research International،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1133774
Modern Language Association (MLA)
Lombardi, Mariangela…[et al.]. Full-Length TrkB Variant in NSCLC Is Associated with Brain Metastasis. BioMed Research International No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1133774
American Medical Association (AMA)
Lombardi, Mariangela& D'Ascanio, Michela& Scarpino, Stefania& Scozzi, Davide& Giordano, Marco& Costarelli, Leopoldo…[et al.]. Full-Length TrkB Variant in NSCLC Is Associated with Brain Metastasis. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1133774
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1133774