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The Neuroprotective Effect of Zingiber cassumunar Roxb. Extract on LPS-Induced Neuronal Cell Loss and Astroglial Activation within the Hippocampus
المؤلفون المشاركون
Kongsui, Ratchaniporn
Sriraksa, Napatr
Thongrong, Sitthisak
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-27
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The systemic administration of lipopolysaccharide (LPS) has been recognized to induce neuroinflammation which plays a significant role in the pathogenesis of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease.
In this study, we aimed to determine the protective effect of Zingiber cassumunar (Z.
cassumunar) or Phlai (in Thai) against LPS-induced neuronal cell loss and the upregulation of glial fibrillary acidic protein (GFAP) of astrocytes in the hippocampus.
Adult male Wistar rats were orally administered with Z.
cassumunar extract at various doses (50, 100, and 200 mg/kg body weight) for 14 days before a single injection of LPS (250 μg/kg/i.p.).
The results indicated that LPS-treated animals exhibited neuronal cell loss and the activation of astrocytes and also increased proinflammatory cytokine interleukin- (IL-) 1β in the hippocampus.
Pretreatment with Z.
cassumunar markedly reduced neuronal cell loss in the hippocampus.
In addition, Z.
cassumunar extract at a dose of 200 mg/kg BW significantly suppressed the inflammatory response by reducing the expression of GFAP and IL-1ß in the hippocampus.
Therefore, the results suggested that Z.
cassumunar extract might be valuable as a neuroprotective agent in neuroinflammation-induced brain damage.
However, further investigations are essential to validate the possible active ingredients and mechanisms of its neuroprotective effect.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kongsui, Ratchaniporn& Sriraksa, Napatr& Thongrong, Sitthisak. 2020. The Neuroprotective Effect of Zingiber cassumunar Roxb. Extract on LPS-Induced Neuronal Cell Loss and Astroglial Activation within the Hippocampus. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1133826
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kongsui, Ratchaniporn…[et al.]. The Neuroprotective Effect of Zingiber cassumunar Roxb. Extract on LPS-Induced Neuronal Cell Loss and Astroglial Activation within the Hippocampus. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1133826
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kongsui, Ratchaniporn& Sriraksa, Napatr& Thongrong, Sitthisak. The Neuroprotective Effect of Zingiber cassumunar Roxb. Extract on LPS-Induced Neuronal Cell Loss and Astroglial Activation within the Hippocampus. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1133826
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1133826
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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