![](/images/graphics-bg.png)
The Neuroprotective Effect of Zingiber cassumunar Roxb. Extract on LPS-Induced Neuronal Cell Loss and Astroglial Activation within the Hippocampus
Joint Authors
Kongsui, Ratchaniporn
Sriraksa, Napatr
Thongrong, Sitthisak
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The systemic administration of lipopolysaccharide (LPS) has been recognized to induce neuroinflammation which plays a significant role in the pathogenesis of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease.
In this study, we aimed to determine the protective effect of Zingiber cassumunar (Z.
cassumunar) or Phlai (in Thai) against LPS-induced neuronal cell loss and the upregulation of glial fibrillary acidic protein (GFAP) of astrocytes in the hippocampus.
Adult male Wistar rats were orally administered with Z.
cassumunar extract at various doses (50, 100, and 200 mg/kg body weight) for 14 days before a single injection of LPS (250 μg/kg/i.p.).
The results indicated that LPS-treated animals exhibited neuronal cell loss and the activation of astrocytes and also increased proinflammatory cytokine interleukin- (IL-) 1β in the hippocampus.
Pretreatment with Z.
cassumunar markedly reduced neuronal cell loss in the hippocampus.
In addition, Z.
cassumunar extract at a dose of 200 mg/kg BW significantly suppressed the inflammatory response by reducing the expression of GFAP and IL-1ß in the hippocampus.
Therefore, the results suggested that Z.
cassumunar extract might be valuable as a neuroprotective agent in neuroinflammation-induced brain damage.
However, further investigations are essential to validate the possible active ingredients and mechanisms of its neuroprotective effect.
American Psychological Association (APA)
Kongsui, Ratchaniporn& Sriraksa, Napatr& Thongrong, Sitthisak. 2020. The Neuroprotective Effect of Zingiber cassumunar Roxb. Extract on LPS-Induced Neuronal Cell Loss and Astroglial Activation within the Hippocampus. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1133826
Modern Language Association (MLA)
Kongsui, Ratchaniporn…[et al.]. The Neuroprotective Effect of Zingiber cassumunar Roxb. Extract on LPS-Induced Neuronal Cell Loss and Astroglial Activation within the Hippocampus. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1133826
American Medical Association (AMA)
Kongsui, Ratchaniporn& Sriraksa, Napatr& Thongrong, Sitthisak. The Neuroprotective Effect of Zingiber cassumunar Roxb. Extract on LPS-Induced Neuronal Cell Loss and Astroglial Activation within the Hippocampus. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1133826
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1133826