No Significant Difference between Plasma miRNAs and Plasma-Derived Exosomal miRNAs from Healthy People
المؤلفون المشاركون
Tian, Fei
Li, Rui
Chen, Zhenzhu
Shen, Yanting
Ge, Qinyu
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-06-01
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background.
MicroRNAs (miRNAs) are small noncoding RNAs that are involved in many biological regulation processes.
Studies have reported that miRNAs are enriched in human plasma and plasma-derived exosome as novel diagnostic biomarkers.
The aim of this study was to determine whether the miRNA expression levels are different between plasma and plasma-derived exosome.
Methods.
We sequenced and quantified the miRNAs in plasma and exosome from healthy blood samples and validated three miRNAs in the two groups of lung cancer samples by qRT-PCR.
Results.
The sequencing results showed that only several of miRNAs were differential, while the qRT-PCR further validated that most of them did not have the consistent differences.
However, the levels of two upregulated miRNAs (miR-181b-5p and miR-21-5p) in lung cancer were significantly higher in exosomes than plasma.
Conclusions.
To the best of our knowledge, this study is the first to compare the expression levels of miRNAs between plasma and exosome in healthy blood samples.
Our data suggested that the miRNA levels were similar in the two parts of the healthy people, whereas the two onco-miRNAs were significantly enriched in the exosome of lung cancer patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tian, Fei& Shen, Yanting& Chen, Zhenzhu& Li, Rui& Ge, Qinyu. 2017. No Significant Difference between Plasma miRNAs and Plasma-Derived Exosomal miRNAs from Healthy People. BioMed Research International،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1133827
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tian, Fei…[et al.]. No Significant Difference between Plasma miRNAs and Plasma-Derived Exosomal miRNAs from Healthy People. BioMed Research International No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1133827
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tian, Fei& Shen, Yanting& Chen, Zhenzhu& Li, Rui& Ge, Qinyu. No Significant Difference between Plasma miRNAs and Plasma-Derived Exosomal miRNAs from Healthy People. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1133827
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1133827
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر