Association between APOBEC3H-Mediated Demethylation and Immune Landscape in Head and Neck Squamous Carcinoma
المؤلفون المشاركون
Cheng, Bin
Liu, Qin
Luo, Yue-wen
Cao, Ruo-yan
Pan, Xue
Chen, Xi-juan
Zhang, Si-yuan
Zhang, Wei-lin
Zhou, Jia-ying
Ren, Xian-yue
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-07-25
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Immunotherapy has been demonstrated as a promising strategy in controlling head and neck squamous cell carcinoma (HNSC).
The AID/APOBEC family is well characterized as DNA mutator and considered to play critical roles in immune responses in HNSC.
However, the expression pattern and deamination-dependent demethylation roles of AID/APOBECs in HNSC are unclear.
In this study, the RNA-seq and DNA methylation profiles of HNSC from TCGA database and cell-based experiments were applied to analyze the relationships between AID/APOBEC expression levels, patients’ clinical outcomes, methylation alterations, and immune responses.
Here, we found that APOBEC3H was abnormally upregulated in HNSC patients.
HPV+ patients tended to have higher APOBEC3H levels than HPV- patients.
Remarkably, patients with high APOBEC3H levels showed a favorable overall survival.
Furthermore, tumors with high APOBEC3H levels exhibited a genome-wide DNA hypomethylation pattern.
APOBEC3H was identified to demethylate and upregulate CXCL10 and improve CD8+ T cell tumor infiltration in the tumor microenvironment.
Collectively, APOBEC3H plays critical roles in CD8+ T cell immune infiltration and activation in HNSC, which may be a potential biomarker for oncoimmunotherapy in HNSC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Qin& Luo, Yue-wen& Cao, Ruo-yan& Pan, Xue& Chen, Xi-juan& Zhang, Si-yuan…[et al.]. 2020. Association between APOBEC3H-Mediated Demethylation and Immune Landscape in Head and Neck Squamous Carcinoma. BioMed Research International،Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1134033
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Qin…[et al.]. Association between APOBEC3H-Mediated Demethylation and Immune Landscape in Head and Neck Squamous Carcinoma. BioMed Research International No. 2020 (2020), pp.1-17.
https://search.emarefa.net/detail/BIM-1134033
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Qin& Luo, Yue-wen& Cao, Ruo-yan& Pan, Xue& Chen, Xi-juan& Zhang, Si-yuan…[et al.]. Association between APOBEC3H-Mediated Demethylation and Immune Landscape in Head and Neck Squamous Carcinoma. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1134033
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1134033
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر