![](/images/graphics-bg.png)
Association between APOBEC3H-Mediated Demethylation and Immune Landscape in Head and Neck Squamous Carcinoma
Joint Authors
Cheng, Bin
Liu, Qin
Luo, Yue-wen
Cao, Ruo-yan
Pan, Xue
Chen, Xi-juan
Zhang, Si-yuan
Zhang, Wei-lin
Zhou, Jia-ying
Ren, Xian-yue
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-25
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Immunotherapy has been demonstrated as a promising strategy in controlling head and neck squamous cell carcinoma (HNSC).
The AID/APOBEC family is well characterized as DNA mutator and considered to play critical roles in immune responses in HNSC.
However, the expression pattern and deamination-dependent demethylation roles of AID/APOBECs in HNSC are unclear.
In this study, the RNA-seq and DNA methylation profiles of HNSC from TCGA database and cell-based experiments were applied to analyze the relationships between AID/APOBEC expression levels, patients’ clinical outcomes, methylation alterations, and immune responses.
Here, we found that APOBEC3H was abnormally upregulated in HNSC patients.
HPV+ patients tended to have higher APOBEC3H levels than HPV- patients.
Remarkably, patients with high APOBEC3H levels showed a favorable overall survival.
Furthermore, tumors with high APOBEC3H levels exhibited a genome-wide DNA hypomethylation pattern.
APOBEC3H was identified to demethylate and upregulate CXCL10 and improve CD8+ T cell tumor infiltration in the tumor microenvironment.
Collectively, APOBEC3H plays critical roles in CD8+ T cell immune infiltration and activation in HNSC, which may be a potential biomarker for oncoimmunotherapy in HNSC.
American Psychological Association (APA)
Liu, Qin& Luo, Yue-wen& Cao, Ruo-yan& Pan, Xue& Chen, Xi-juan& Zhang, Si-yuan…[et al.]. 2020. Association between APOBEC3H-Mediated Demethylation and Immune Landscape in Head and Neck Squamous Carcinoma. BioMed Research International،Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1134033
Modern Language Association (MLA)
Liu, Qin…[et al.]. Association between APOBEC3H-Mediated Demethylation and Immune Landscape in Head and Neck Squamous Carcinoma. BioMed Research International No. 2020 (2020), pp.1-17.
https://search.emarefa.net/detail/BIM-1134033
American Medical Association (AMA)
Liu, Qin& Luo, Yue-wen& Cao, Ruo-yan& Pan, Xue& Chen, Xi-juan& Zhang, Si-yuan…[et al.]. Association between APOBEC3H-Mediated Demethylation and Immune Landscape in Head and Neck Squamous Carcinoma. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1134033
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134033