Combined Treatment with an Anticoagulant and a Vasodilator Prevents Steroid-Associated Osteonecrosis of Rabbit Femoral Heads by Improving Hypercoagulability
المؤلفون المشاركون
Wang, Benjie
Wei, Xiaowei
Qin, Kai-Rong
Cao, Fang
Liu, Ge
Wang, Wei
Lu, Faqiang
Yang, Fan
Kang, Kai
Wang, Yongxuan
Yang, Jiahui
Zhao, Dewei
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-10-19
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Steroid-associated osteonecrosis of the femoral head remains a challenging problem in orthopedics worldwide.
One pathomechanism is ischemia of the femoral head, as a result of thrombus formation and vasoconstriction.
The present study investigates the effects of combination prevention with enoxaparin and EGb 761 on steroid-associated ONFH in rabbits.
Rabbits were randomly divided into 5 groups (control group, model group, enoxaparin group, ginkgo group, and combination group).
With the exception of the control group, the groups of rabbits were modeled with lipopolysaccharide and methylprednisolone acetate.
Starting with modeling, the enoxaparin group and ginkgo group were injected with 1 μg/kg/day enoxaparin subcutaneously and orally given 40 mg/kg/day EGb 761 for 4 weeks, respectively; the combination group received both treatments.
After modeling for 6 weeks, the hematology data indicated prolonged PT and APTT in the three prevention groups.
The micro-CT examination revealed higher bone density and better structure; histomorphometry revealed significant pathological changes.
Immunohistochemistry revealed higher expression of BMP-2 and VEGF, thus revealing better osteogenesis and angiogenesis activities.
Among the three prevention groups, the combination group had the most efficient results.
In conclusion, the combined prevention with an anticoagulant and a vasodilator has the potential to decrease the incidence of steroid-associated ONFH in rabbits.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cao, Fang& Liu, Ge& Wang, Wei& Wang, Benjie& Wei, Xiaowei& Lu, Faqiang…[et al.]. 2017. Combined Treatment with an Anticoagulant and a Vasodilator Prevents Steroid-Associated Osteonecrosis of Rabbit Femoral Heads by Improving Hypercoagulability. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1134074
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cao, Fang…[et al.]. Combined Treatment with an Anticoagulant and a Vasodilator Prevents Steroid-Associated Osteonecrosis of Rabbit Femoral Heads by Improving Hypercoagulability. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1134074
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cao, Fang& Liu, Ge& Wang, Wei& Wang, Benjie& Wei, Xiaowei& Lu, Faqiang…[et al.]. Combined Treatment with an Anticoagulant and a Vasodilator Prevents Steroid-Associated Osteonecrosis of Rabbit Femoral Heads by Improving Hypercoagulability. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1134074
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1134074
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر