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Combined Treatment with an Anticoagulant and a Vasodilator Prevents Steroid-Associated Osteonecrosis of Rabbit Femoral Heads by Improving Hypercoagulability
Joint Authors
Wang, Benjie
Wei, Xiaowei
Qin, Kai-Rong
Cao, Fang
Liu, Ge
Wang, Wei
Lu, Faqiang
Yang, Fan
Kang, Kai
Wang, Yongxuan
Yang, Jiahui
Zhao, Dewei
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-19
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Steroid-associated osteonecrosis of the femoral head remains a challenging problem in orthopedics worldwide.
One pathomechanism is ischemia of the femoral head, as a result of thrombus formation and vasoconstriction.
The present study investigates the effects of combination prevention with enoxaparin and EGb 761 on steroid-associated ONFH in rabbits.
Rabbits were randomly divided into 5 groups (control group, model group, enoxaparin group, ginkgo group, and combination group).
With the exception of the control group, the groups of rabbits were modeled with lipopolysaccharide and methylprednisolone acetate.
Starting with modeling, the enoxaparin group and ginkgo group were injected with 1 μg/kg/day enoxaparin subcutaneously and orally given 40 mg/kg/day EGb 761 for 4 weeks, respectively; the combination group received both treatments.
After modeling for 6 weeks, the hematology data indicated prolonged PT and APTT in the three prevention groups.
The micro-CT examination revealed higher bone density and better structure; histomorphometry revealed significant pathological changes.
Immunohistochemistry revealed higher expression of BMP-2 and VEGF, thus revealing better osteogenesis and angiogenesis activities.
Among the three prevention groups, the combination group had the most efficient results.
In conclusion, the combined prevention with an anticoagulant and a vasodilator has the potential to decrease the incidence of steroid-associated ONFH in rabbits.
American Psychological Association (APA)
Cao, Fang& Liu, Ge& Wang, Wei& Wang, Benjie& Wei, Xiaowei& Lu, Faqiang…[et al.]. 2017. Combined Treatment with an Anticoagulant and a Vasodilator Prevents Steroid-Associated Osteonecrosis of Rabbit Femoral Heads by Improving Hypercoagulability. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1134074
Modern Language Association (MLA)
Cao, Fang…[et al.]. Combined Treatment with an Anticoagulant and a Vasodilator Prevents Steroid-Associated Osteonecrosis of Rabbit Femoral Heads by Improving Hypercoagulability. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1134074
American Medical Association (AMA)
Cao, Fang& Liu, Ge& Wang, Wei& Wang, Benjie& Wei, Xiaowei& Lu, Faqiang…[et al.]. Combined Treatment with an Anticoagulant and a Vasodilator Prevents Steroid-Associated Osteonecrosis of Rabbit Femoral Heads by Improving Hypercoagulability. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1134074
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134074