Peptidomics Analysis Discloses That Novel Bioactive Peptides Participate in Necrotizing Enterocolitis in a Rat Model
المؤلفون المشاركون
Wang, Xiaolei
Zhu, Yuting
Wang, Changlin
Yu, Renqiang
Fan, Jianfeng
Jin, Weilai
Shi, Yingzuo
Jing, Yulei
Li, Zhengying
Zhou, Jian
Zhang, Le
Liu, Yiwen
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-12-31
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Necrotizing enterocolitis (NEC) is a common devastating gastrointestinal disease in premature infants, the molecular mechanisms of which have not been fully elucidated.
Recently, endogenous peptides have garnered much attention owing to their role in diagnosis and treatment.
However, changes in the peptide expression of NEC intestinal tissues remain poorly understood.
In the present study, a comparative peptidomics profiling analysis was performed between NEC and control intestinal tissues via liquid chromatography-tandem mass spectrometry (LC-MS).
In total, 103 upregulated and 73 downregulated peptides were identified in the intestinal tissues (fold change≥1.5, p<0.05).
Bioinformatics analysis revealed that these differentially expressed peptides were significantly associated with NEC pathophysiology, including apoptosis, the TGF-β signaling pathway, the Wnt signaling pathway, and the MAPK signaling pathway.
Furthermore, two putative peptides could inhibit apoptosis and promote the migration of intestinal epithelial cells induced by lipopolysaccharide; these peptides were derived from the protein domains MT1 and EZRI, respectively.
In conclusion, our study revealed that endogenous peptides are involved in the pathophysiologic mechanism of NEC; nevertheless, further exploration is required in this regard.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Yiwen& Wang, Changlin& Yu, Renqiang& Fan, Jianfeng& Jin, Weilai& Zhu, Yuting…[et al.]. 2020. Peptidomics Analysis Discloses That Novel Bioactive Peptides Participate in Necrotizing Enterocolitis in a Rat Model. BioMed Research International،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1134120
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Yiwen…[et al.]. Peptidomics Analysis Discloses That Novel Bioactive Peptides Participate in Necrotizing Enterocolitis in a Rat Model. BioMed Research International No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1134120
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Yiwen& Wang, Changlin& Yu, Renqiang& Fan, Jianfeng& Jin, Weilai& Zhu, Yuting…[et al.]. Peptidomics Analysis Discloses That Novel Bioactive Peptides Participate in Necrotizing Enterocolitis in a Rat Model. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1134120
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1134120
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر