Peptidomics Analysis Discloses That Novel Bioactive Peptides Participate in Necrotizing Enterocolitis in a Rat Model
Joint Authors
Wang, Xiaolei
Zhu, Yuting
Wang, Changlin
Yu, Renqiang
Fan, Jianfeng
Jin, Weilai
Shi, Yingzuo
Jing, Yulei
Li, Zhengying
Zhou, Jian
Zhang, Le
Liu, Yiwen
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-31
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Necrotizing enterocolitis (NEC) is a common devastating gastrointestinal disease in premature infants, the molecular mechanisms of which have not been fully elucidated.
Recently, endogenous peptides have garnered much attention owing to their role in diagnosis and treatment.
However, changes in the peptide expression of NEC intestinal tissues remain poorly understood.
In the present study, a comparative peptidomics profiling analysis was performed between NEC and control intestinal tissues via liquid chromatography-tandem mass spectrometry (LC-MS).
In total, 103 upregulated and 73 downregulated peptides were identified in the intestinal tissues (fold change≥1.5, p<0.05).
Bioinformatics analysis revealed that these differentially expressed peptides were significantly associated with NEC pathophysiology, including apoptosis, the TGF-β signaling pathway, the Wnt signaling pathway, and the MAPK signaling pathway.
Furthermore, two putative peptides could inhibit apoptosis and promote the migration of intestinal epithelial cells induced by lipopolysaccharide; these peptides were derived from the protein domains MT1 and EZRI, respectively.
In conclusion, our study revealed that endogenous peptides are involved in the pathophysiologic mechanism of NEC; nevertheless, further exploration is required in this regard.
American Psychological Association (APA)
Liu, Yiwen& Wang, Changlin& Yu, Renqiang& Fan, Jianfeng& Jin, Weilai& Zhu, Yuting…[et al.]. 2020. Peptidomics Analysis Discloses That Novel Bioactive Peptides Participate in Necrotizing Enterocolitis in a Rat Model. BioMed Research International،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1134120
Modern Language Association (MLA)
Liu, Yiwen…[et al.]. Peptidomics Analysis Discloses That Novel Bioactive Peptides Participate in Necrotizing Enterocolitis in a Rat Model. BioMed Research International No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1134120
American Medical Association (AMA)
Liu, Yiwen& Wang, Changlin& Yu, Renqiang& Fan, Jianfeng& Jin, Weilai& Zhu, Yuting…[et al.]. Peptidomics Analysis Discloses That Novel Bioactive Peptides Participate in Necrotizing Enterocolitis in a Rat Model. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1134120
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134120