Pulsed Vincristine Therapy in Steroid-Resistant Nephrotic Syndrome
المؤلفون المشاركون
Thalgahagoda, Shenal
Abeyagunawardena, Shamali
Jayaweera, Heshan
Karunadasa, Umeshi Ishanthika
Abeyagunawardena, Asiri Samantha
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-05-29
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Steroid-resistant nephrotic syndrome (SRNS) poses a therapeutic challenge for the paediatric nephrologist.
As relentless progression to renal failure occurs with continued proteinuria, such patients will be treated with different cytotoxic medications with variable success rates and side-effects.
We present here our findings on administering the anticancer drug vincristine for SRNS patients at a single centre in Sri Lanka.
Methods.
Between 2002 and 2007, fifty-four children presenting with steroid and cyclophosphamide resistance were treated with vincristine at 1.5 mg/m2 in weekly intravenous pulses for 8 weeks along with a tapering steroid regimen of 6 months.
All patients were closely followed up for 5 years.
Results.
Of the 54 patients 39 were males and 15 were females (age range 3.5–11.6 years, median 6.1 years).
At the end of the treatment course, 21 patients achieved complete remission while 7 had partial remission and no response was seen in 26 patients.
Sustained remission at 6, 12, 24, and 60 months were 15 (27.78%), 11 (20.37%), 9 (16.67%), and 7 (12.96%), respectively.
Most side-effects observed were reversible and no serious side-effects were noted during vincristine therapy.
Conclusion.
Although its therapeutic mechanisms in nephrotic syndrome are still not elucidated, vincristine appears to be a potent alternative that could be considered for treating SRNS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Thalgahagoda, Shenal& Abeyagunawardena, Shamali& Jayaweera, Heshan& Karunadasa, Umeshi Ishanthika& Abeyagunawardena, Asiri Samantha. 2017. Pulsed Vincristine Therapy in Steroid-Resistant Nephrotic Syndrome. BioMed Research International،Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1134167
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Thalgahagoda, Shenal…[et al.]. Pulsed Vincristine Therapy in Steroid-Resistant Nephrotic Syndrome. BioMed Research International No. 2017 (2017), pp.1-4.
https://search.emarefa.net/detail/BIM-1134167
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Thalgahagoda, Shenal& Abeyagunawardena, Shamali& Jayaweera, Heshan& Karunadasa, Umeshi Ishanthika& Abeyagunawardena, Asiri Samantha. Pulsed Vincristine Therapy in Steroid-Resistant Nephrotic Syndrome. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1134167
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1134167
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر