Pulsed Vincristine Therapy in Steroid-Resistant Nephrotic Syndrome
Joint Authors
Thalgahagoda, Shenal
Abeyagunawardena, Shamali
Jayaweera, Heshan
Karunadasa, Umeshi Ishanthika
Abeyagunawardena, Asiri Samantha
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-29
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Steroid-resistant nephrotic syndrome (SRNS) poses a therapeutic challenge for the paediatric nephrologist.
As relentless progression to renal failure occurs with continued proteinuria, such patients will be treated with different cytotoxic medications with variable success rates and side-effects.
We present here our findings on administering the anticancer drug vincristine for SRNS patients at a single centre in Sri Lanka.
Methods.
Between 2002 and 2007, fifty-four children presenting with steroid and cyclophosphamide resistance were treated with vincristine at 1.5 mg/m2 in weekly intravenous pulses for 8 weeks along with a tapering steroid regimen of 6 months.
All patients were closely followed up for 5 years.
Results.
Of the 54 patients 39 were males and 15 were females (age range 3.5–11.6 years, median 6.1 years).
At the end of the treatment course, 21 patients achieved complete remission while 7 had partial remission and no response was seen in 26 patients.
Sustained remission at 6, 12, 24, and 60 months were 15 (27.78%), 11 (20.37%), 9 (16.67%), and 7 (12.96%), respectively.
Most side-effects observed were reversible and no serious side-effects were noted during vincristine therapy.
Conclusion.
Although its therapeutic mechanisms in nephrotic syndrome are still not elucidated, vincristine appears to be a potent alternative that could be considered for treating SRNS.
American Psychological Association (APA)
Thalgahagoda, Shenal& Abeyagunawardena, Shamali& Jayaweera, Heshan& Karunadasa, Umeshi Ishanthika& Abeyagunawardena, Asiri Samantha. 2017. Pulsed Vincristine Therapy in Steroid-Resistant Nephrotic Syndrome. BioMed Research International،Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1134167
Modern Language Association (MLA)
Thalgahagoda, Shenal…[et al.]. Pulsed Vincristine Therapy in Steroid-Resistant Nephrotic Syndrome. BioMed Research International No. 2017 (2017), pp.1-4.
https://search.emarefa.net/detail/BIM-1134167
American Medical Association (AMA)
Thalgahagoda, Shenal& Abeyagunawardena, Shamali& Jayaweera, Heshan& Karunadasa, Umeshi Ishanthika& Abeyagunawardena, Asiri Samantha. Pulsed Vincristine Therapy in Steroid-Resistant Nephrotic Syndrome. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1134167
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134167