Friend or Foe? Essential Roles of Osteoclast in Maintaining Skeletal Health

المؤلفون المشاركون

Li, Gang
Li, Ziqing
Wang, Haixing
Yang, Guangpu
Xiao, Yinbo
Luo, Guotian

المصدر

BioMed Research International

العدد

المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2020-03-04

دولة النشر

مصر

عدد الصفحات

10

التخصصات الرئيسية

الطب البشري

الملخص EN

Heightened activity of osteoclast is considered to be the culprit in breaking the balance during bone remodeling in pathological conditions, such as osteoporosis.

As a “foe” of skeletal health, many antiosteoporosis therapies aim to inhibit osteoclastogenesis.

However, bone remodeling is a dynamic process that requires the subtle coordination of osteoclasts and osteoblasts.

Severe suppression of osteoclast differentiation will impair bone formation because of the coupling effect.

Thus, understanding the complex roles of osteoclast in maintaining proper bone remodeling is highly warranted to develop better management of osteoporosis.

This review aimed to determine the varied roles of osteoclasts in maintaining skeletal health and to highlight the positive roles of osteoclasts in maintaining normal bone remodeling.

Generally, osteoclasts interact with osteocytes to initiate targeted bone remodeling and have crosstalk with mesenchymal stem cells and osteoblasts via secreted factors or cell-cell contact to promote bone formation.

We believe that a better outcome of bone remodeling disorders will be achieved when proper strategies are made to coordinate osteoclasts and osteoblasts in managing such disorders.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Wang, Haixing& Yang, Guangpu& Xiao, Yinbo& Luo, Guotian& Li, Gang& Li, Ziqing. 2020. Friend or Foe? Essential Roles of Osteoclast in Maintaining Skeletal Health. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1134186

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Wang, Haixing…[et al.]. Friend or Foe? Essential Roles of Osteoclast in Maintaining Skeletal Health. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1134186

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Wang, Haixing& Yang, Guangpu& Xiao, Yinbo& Luo, Guotian& Li, Gang& Li, Ziqing. Friend or Foe? Essential Roles of Osteoclast in Maintaining Skeletal Health. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1134186

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1134186