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Friend or Foe? Essential Roles of Osteoclast in Maintaining Skeletal Health
Joint Authors
Li, Gang
Li, Ziqing
Wang, Haixing
Yang, Guangpu
Xiao, Yinbo
Luo, Guotian
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Heightened activity of osteoclast is considered to be the culprit in breaking the balance during bone remodeling in pathological conditions, such as osteoporosis.
As a “foe” of skeletal health, many antiosteoporosis therapies aim to inhibit osteoclastogenesis.
However, bone remodeling is a dynamic process that requires the subtle coordination of osteoclasts and osteoblasts.
Severe suppression of osteoclast differentiation will impair bone formation because of the coupling effect.
Thus, understanding the complex roles of osteoclast in maintaining proper bone remodeling is highly warranted to develop better management of osteoporosis.
This review aimed to determine the varied roles of osteoclasts in maintaining skeletal health and to highlight the positive roles of osteoclasts in maintaining normal bone remodeling.
Generally, osteoclasts interact with osteocytes to initiate targeted bone remodeling and have crosstalk with mesenchymal stem cells and osteoblasts via secreted factors or cell-cell contact to promote bone formation.
We believe that a better outcome of bone remodeling disorders will be achieved when proper strategies are made to coordinate osteoclasts and osteoblasts in managing such disorders.
American Psychological Association (APA)
Wang, Haixing& Yang, Guangpu& Xiao, Yinbo& Luo, Guotian& Li, Gang& Li, Ziqing. 2020. Friend or Foe? Essential Roles of Osteoclast in Maintaining Skeletal Health. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1134186
Modern Language Association (MLA)
Wang, Haixing…[et al.]. Friend or Foe? Essential Roles of Osteoclast in Maintaining Skeletal Health. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1134186
American Medical Association (AMA)
Wang, Haixing& Yang, Guangpu& Xiao, Yinbo& Luo, Guotian& Li, Gang& Li, Ziqing. Friend or Foe? Essential Roles of Osteoclast in Maintaining Skeletal Health. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1134186
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134186