Biocompatibility and Effectiveness Evaluation of a New Hemostatic Embolization Agent: Thrombin Loaded Alginate Calcium Microsphere

المؤلفون المشاركون

Xuan, Fengqi
Rong, Jingjing
Liang, Ming
Zhang, Xuwen
Sun, Jingyang
Zhao, Lijun
Li, Yang
Liu, Dan
Li, Fei
Wang, Xiaozeng
Han, Yaling

المصدر

BioMed Research International

العدد

المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2017-02-16

دولة النشر

مصر

عدد الصفحات

10

التخصصات الرئيسية

الطب البشري

الملخص EN

Background.

Until now, there has been no ideal embolization agent for hemorrhage in interventional treatment.

In this study, the thrombin was encapsulated in alginate calcium microsphere using electrostatic droplet technique to produce new embolization agent: thrombin loaded alginate calcium microspheres (TACMs).

Objectives.

The present work was to evaluate the biocompatibility and hemostatic efficiency of TACMs.

Methods.

Cell cytotoxicity, hemolysis, and superselective embolization of dog liver arteries were performed to investigate the biocompatibility of TACMs.

To clarify the embolic effect of TACMs mixed thrombus in vivo, hepatic artery injury animal model of 6 beagles was established and transcatheter artery embolization for bleeding was performed.

Results.

Coculture with VECs revealed the noncytotoxicity of TACMs, and the hemolysis experiment was negligible.

Moreover, the histological study of TACMs in liver blood vessel showed signs of a slight inflammatory reaction.

The results of transcatheter application of TACMs mixed thrombus for bleeding showed that the blood flow was shut down completely after the TACMs mixed thrombus was delivered and the postprocedural survival rate of animal models at 12 weeks was 100%.

Conclusions.

With their good biocompatibility and superior hemostatic efficiency, TACMs might be a promising new hemostatic agent with a wide range of potential applications.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Xuan, Fengqi& Rong, Jingjing& Liang, Ming& Zhang, Xuwen& Sun, Jingyang& Zhao, Lijun…[et al.]. 2017. Biocompatibility and Effectiveness Evaluation of a New Hemostatic Embolization Agent: Thrombin Loaded Alginate Calcium Microsphere. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1134296

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Xuan, Fengqi…[et al.]. Biocompatibility and Effectiveness Evaluation of a New Hemostatic Embolization Agent: Thrombin Loaded Alginate Calcium Microsphere. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1134296

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Xuan, Fengqi& Rong, Jingjing& Liang, Ming& Zhang, Xuwen& Sun, Jingyang& Zhao, Lijun…[et al.]. Biocompatibility and Effectiveness Evaluation of a New Hemostatic Embolization Agent: Thrombin Loaded Alginate Calcium Microsphere. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1134296

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1134296