Biocompatibility and Effectiveness Evaluation of a New Hemostatic Embolization Agent: Thrombin Loaded Alginate Calcium Microsphere
المؤلفون المشاركون
Xuan, Fengqi
Rong, Jingjing
Liang, Ming
Zhang, Xuwen
Sun, Jingyang
Zhao, Lijun
Li, Yang
Liu, Dan
Li, Fei
Wang, Xiaozeng
Han, Yaling
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-16
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Until now, there has been no ideal embolization agent for hemorrhage in interventional treatment.
In this study, the thrombin was encapsulated in alginate calcium microsphere using electrostatic droplet technique to produce new embolization agent: thrombin loaded alginate calcium microspheres (TACMs).
Objectives.
The present work was to evaluate the biocompatibility and hemostatic efficiency of TACMs.
Methods.
Cell cytotoxicity, hemolysis, and superselective embolization of dog liver arteries were performed to investigate the biocompatibility of TACMs.
To clarify the embolic effect of TACMs mixed thrombus in vivo, hepatic artery injury animal model of 6 beagles was established and transcatheter artery embolization for bleeding was performed.
Results.
Coculture with VECs revealed the noncytotoxicity of TACMs, and the hemolysis experiment was negligible.
Moreover, the histological study of TACMs in liver blood vessel showed signs of a slight inflammatory reaction.
The results of transcatheter application of TACMs mixed thrombus for bleeding showed that the blood flow was shut down completely after the TACMs mixed thrombus was delivered and the postprocedural survival rate of animal models at 12 weeks was 100%.
Conclusions.
With their good biocompatibility and superior hemostatic efficiency, TACMs might be a promising new hemostatic agent with a wide range of potential applications.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xuan, Fengqi& Rong, Jingjing& Liang, Ming& Zhang, Xuwen& Sun, Jingyang& Zhao, Lijun…[et al.]. 2017. Biocompatibility and Effectiveness Evaluation of a New Hemostatic Embolization Agent: Thrombin Loaded Alginate Calcium Microsphere. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1134296
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xuan, Fengqi…[et al.]. Biocompatibility and Effectiveness Evaluation of a New Hemostatic Embolization Agent: Thrombin Loaded Alginate Calcium Microsphere. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1134296
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xuan, Fengqi& Rong, Jingjing& Liang, Ming& Zhang, Xuwen& Sun, Jingyang& Zhao, Lijun…[et al.]. Biocompatibility and Effectiveness Evaluation of a New Hemostatic Embolization Agent: Thrombin Loaded Alginate Calcium Microsphere. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1134296
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1134296
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر