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Biocompatibility and Effectiveness Evaluation of a New Hemostatic Embolization Agent: Thrombin Loaded Alginate Calcium Microsphere
Joint Authors
Xuan, Fengqi
Rong, Jingjing
Liang, Ming
Zhang, Xuwen
Sun, Jingyang
Zhao, Lijun
Li, Yang
Liu, Dan
Li, Fei
Wang, Xiaozeng
Han, Yaling
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Until now, there has been no ideal embolization agent for hemorrhage in interventional treatment.
In this study, the thrombin was encapsulated in alginate calcium microsphere using electrostatic droplet technique to produce new embolization agent: thrombin loaded alginate calcium microspheres (TACMs).
Objectives.
The present work was to evaluate the biocompatibility and hemostatic efficiency of TACMs.
Methods.
Cell cytotoxicity, hemolysis, and superselective embolization of dog liver arteries were performed to investigate the biocompatibility of TACMs.
To clarify the embolic effect of TACMs mixed thrombus in vivo, hepatic artery injury animal model of 6 beagles was established and transcatheter artery embolization for bleeding was performed.
Results.
Coculture with VECs revealed the noncytotoxicity of TACMs, and the hemolysis experiment was negligible.
Moreover, the histological study of TACMs in liver blood vessel showed signs of a slight inflammatory reaction.
The results of transcatheter application of TACMs mixed thrombus for bleeding showed that the blood flow was shut down completely after the TACMs mixed thrombus was delivered and the postprocedural survival rate of animal models at 12 weeks was 100%.
Conclusions.
With their good biocompatibility and superior hemostatic efficiency, TACMs might be a promising new hemostatic agent with a wide range of potential applications.
American Psychological Association (APA)
Xuan, Fengqi& Rong, Jingjing& Liang, Ming& Zhang, Xuwen& Sun, Jingyang& Zhao, Lijun…[et al.]. 2017. Biocompatibility and Effectiveness Evaluation of a New Hemostatic Embolization Agent: Thrombin Loaded Alginate Calcium Microsphere. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1134296
Modern Language Association (MLA)
Xuan, Fengqi…[et al.]. Biocompatibility and Effectiveness Evaluation of a New Hemostatic Embolization Agent: Thrombin Loaded Alginate Calcium Microsphere. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1134296
American Medical Association (AMA)
Xuan, Fengqi& Rong, Jingjing& Liang, Ming& Zhang, Xuwen& Sun, Jingyang& Zhao, Lijun…[et al.]. Biocompatibility and Effectiveness Evaluation of a New Hemostatic Embolization Agent: Thrombin Loaded Alginate Calcium Microsphere. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1134296
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134296