Potential Role of MicroRNA-375 as Biomarker in Human Cancers Detection: A Meta-Analysis
المؤلفون المشاركون
Zhang, Guoxin
Yan, Jin
She, Qiang
Shen, Xiaoran
Zhang, Yifeng
Liu, Bingtuan
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-11-13
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The association between circulating microRNA-375 (miR-375) expression and cancers has been studied; however, the results are inconsistent.
We searched PubMed, Embase, and Web of Science for studies concerning the diagnostic value of miR-375 for cancer.
The bivariate meta-analysis model was employed to summarize sensitivity, specificity, and diagnostic odds ratio (DOR) for miR-375 in the diagnosis of cancer.
Summary receiver operating characteristic (SROC) curve analysis and the area under the curve (AUC) were also used to check the overall test performance.
A total of 645 cancer patients and 421 cancer-free individuals from 12 studies were contained in this meta-analysis.
The summary estimates revealed that the pooled sensitivity was 78% (95% confidence interval (CI): 64%–87%), the specificity was 74% (95% CI: 62%–84%), the DOR was 10.04 (95% CI: 6.01–16.77), and the AUC was 0.82 (95% CI: 0.79–0.85).
In addition, we found that the diagnostic effect of miR-375 varies according to the race and cancer type.
Our data suggest that miR-375 profiling has a potential to be used as a screening test for cancers but the specific race and cancer should be considered.
More studies on the diagnostic value of miR-375 for cancer are needed in the future.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yan, Jin& She, Qiang& Shen, Xiaoran& Zhang, Yifeng& Liu, Bingtuan& Zhang, Guoxin. 2017. Potential Role of MicroRNA-375 as Biomarker in Human Cancers Detection: A Meta-Analysis. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1134301
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yan, Jin…[et al.]. Potential Role of MicroRNA-375 as Biomarker in Human Cancers Detection: A Meta-Analysis. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1134301
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yan, Jin& She, Qiang& Shen, Xiaoran& Zhang, Yifeng& Liu, Bingtuan& Zhang, Guoxin. Potential Role of MicroRNA-375 as Biomarker in Human Cancers Detection: A Meta-Analysis. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1134301
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1134301
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر