Potential Role of MicroRNA-375 as Biomarker in Human Cancers Detection: A Meta-Analysis
Joint Authors
Zhang, Guoxin
Yan, Jin
She, Qiang
Shen, Xiaoran
Zhang, Yifeng
Liu, Bingtuan
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The association between circulating microRNA-375 (miR-375) expression and cancers has been studied; however, the results are inconsistent.
We searched PubMed, Embase, and Web of Science for studies concerning the diagnostic value of miR-375 for cancer.
The bivariate meta-analysis model was employed to summarize sensitivity, specificity, and diagnostic odds ratio (DOR) for miR-375 in the diagnosis of cancer.
Summary receiver operating characteristic (SROC) curve analysis and the area under the curve (AUC) were also used to check the overall test performance.
A total of 645 cancer patients and 421 cancer-free individuals from 12 studies were contained in this meta-analysis.
The summary estimates revealed that the pooled sensitivity was 78% (95% confidence interval (CI): 64%–87%), the specificity was 74% (95% CI: 62%–84%), the DOR was 10.04 (95% CI: 6.01–16.77), and the AUC was 0.82 (95% CI: 0.79–0.85).
In addition, we found that the diagnostic effect of miR-375 varies according to the race and cancer type.
Our data suggest that miR-375 profiling has a potential to be used as a screening test for cancers but the specific race and cancer should be considered.
More studies on the diagnostic value of miR-375 for cancer are needed in the future.
American Psychological Association (APA)
Yan, Jin& She, Qiang& Shen, Xiaoran& Zhang, Yifeng& Liu, Bingtuan& Zhang, Guoxin. 2017. Potential Role of MicroRNA-375 as Biomarker in Human Cancers Detection: A Meta-Analysis. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1134301
Modern Language Association (MLA)
Yan, Jin…[et al.]. Potential Role of MicroRNA-375 as Biomarker in Human Cancers Detection: A Meta-Analysis. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1134301
American Medical Association (AMA)
Yan, Jin& She, Qiang& Shen, Xiaoran& Zhang, Yifeng& Liu, Bingtuan& Zhang, Guoxin. Potential Role of MicroRNA-375 as Biomarker in Human Cancers Detection: A Meta-Analysis. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1134301
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134301