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Antiurolithiasis Activity of Bioactivity Guided Fraction of Bergenia ligulata against Ethylene Glycol Induced Renal Calculi in Rat
المؤلفون المشاركون
Parveen, Rabea
Khan, Washim
Sharma, Ikshit
Alam, Md. Javed
Ahmad, Iftekhar
Ansari, Mohd Hafizur Rehman
Ahmad, Sayeed
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-02
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Dried rhizome of Bergenia ligulata (pashanbhed) is commonly used as a traditional herbal medicine with a wide range of therapeutic applications including urolithiasis.
Aqueous extract of B.
ligulata was prepared through maceration followed by decoction (mother extract, 35.9% w/w).
Further, polarity based fractions were prepared successively from mother extract which yielded 3.4, 2.9, 5.4, 7.5, and 11.3% w/w of hexane, toluene, dichloromethane (DCM), n-butanol, and water fractions, respectively.
The in vitro, ex vivo, and real-time antiurolithiasis activity of mother extract and fractions were carried out using aggregation assay in synthetic urine and in rat plasma.
The study revealed that DCM fraction has significantly (p<0.05) greater inhibitory potential than other fractions.
Ethylene glycol in drinking water (0.75%, v/v) for 28 days was used for induction of urolithiasis and the curative effects of mother extract and DCM fraction were checked for the level of oxalate, calcium, creatinine, uric acid, and urea of both urine and serum.
Treatment with mother extract and DCM fraction at a dose of 185 mg/kg and 7 mg/kg, respectively, in ethylene glycol induced rats resulted in a significant (p<0.05) decrease in serum and urine markers.
Histological study revealed lower number of calcium oxalate deposits with minimum damage in the kidneys of mother extract and DCM fraction treated rats.
This result provides a scientific basis for its traditional claims.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sharma, Ikshit& Khan, Washim& Parveen, Rabea& Alam, Md. Javed& Ahmad, Iftekhar& Ansari, Mohd Hafizur Rehman…[et al.]. 2017. Antiurolithiasis Activity of Bioactivity Guided Fraction of Bergenia ligulata against Ethylene Glycol Induced Renal Calculi in Rat. BioMed Research International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1134374
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sharma, Ikshit…[et al.]. Antiurolithiasis Activity of Bioactivity Guided Fraction of Bergenia ligulata against Ethylene Glycol Induced Renal Calculi in Rat. BioMed Research International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1134374
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sharma, Ikshit& Khan, Washim& Parveen, Rabea& Alam, Md. Javed& Ahmad, Iftekhar& Ansari, Mohd Hafizur Rehman…[et al.]. Antiurolithiasis Activity of Bioactivity Guided Fraction of Bergenia ligulata against Ethylene Glycol Induced Renal Calculi in Rat. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1134374
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1134374
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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