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Cadmium Exposure as a Putative Risk Factor for the Development of Pancreatic Cancer: Three Different Lines of Evidence
المؤلفون المشاركون
Wallace, David
Schweitzer, Amie
Oluic, Branislav
Micic, Dusan
Djordjevic, Vladimir
Matović, Vesna
Buha, Aleksandra
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-11-16
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Although profoundly studied, etiology of pancreatic cancer (PC) is still rather scant.
Exposure to cadmium (Cd), a ubiquitous metal associated with well-established toxic and carcinogenic properties, has been hypothesized to one putative cause of PC.
Hence, we analyzed recently published observational studies, meta-analyses, and experimental animal and in vitro studies with the aim of summarizing the evidence of Cd involvement in PC development and describing the possible mechanisms.
Consolidation of epidemiological data on PC and exposure to Cd indicated a significant association with an elevated risk of PC among general population exposed to Cd.
Cadmium exposure of laboratory animals was showed to cause PC supporting the findings suggested by human studies.
The concordance with human and animal studies is buttressed by in vitro studies, although in vitro data interpretation is problematic.
In most instances, only significant effects are reported, and the concentrations of Cd are excessive, which would skew interpretation.
Previous reports suggest that oxidative stress, apoptotic changes, and DNA cross-linking and hypermethylation are involved in Cd-mediated carcinogenesis.
Undoubtedly, a significant amount of work is still needed to achieve a better understanding of the Cd involvement in pancreatic cancer which could facilitate prevention, diagnosis, and therapy of this fatal disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Buha, Aleksandra& Wallace, David& Matović, Vesna& Schweitzer, Amie& Oluic, Branislav& Micic, Dusan…[et al.]. 2017. Cadmium Exposure as a Putative Risk Factor for the Development of Pancreatic Cancer: Three Different Lines of Evidence. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1134395
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Buha, Aleksandra…[et al.]. Cadmium Exposure as a Putative Risk Factor for the Development of Pancreatic Cancer: Three Different Lines of Evidence. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1134395
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Buha, Aleksandra& Wallace, David& Matović, Vesna& Schweitzer, Amie& Oluic, Branislav& Micic, Dusan…[et al.]. Cadmium Exposure as a Putative Risk Factor for the Development of Pancreatic Cancer: Three Different Lines of Evidence. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1134395
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1134395
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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