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Cadmium Exposure as a Putative Risk Factor for the Development of Pancreatic Cancer: Three Different Lines of Evidence
Joint Authors
Wallace, David
Schweitzer, Amie
Oluic, Branislav
Micic, Dusan
Djordjevic, Vladimir
Matović, Vesna
Buha, Aleksandra
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Although profoundly studied, etiology of pancreatic cancer (PC) is still rather scant.
Exposure to cadmium (Cd), a ubiquitous metal associated with well-established toxic and carcinogenic properties, has been hypothesized to one putative cause of PC.
Hence, we analyzed recently published observational studies, meta-analyses, and experimental animal and in vitro studies with the aim of summarizing the evidence of Cd involvement in PC development and describing the possible mechanisms.
Consolidation of epidemiological data on PC and exposure to Cd indicated a significant association with an elevated risk of PC among general population exposed to Cd.
Cadmium exposure of laboratory animals was showed to cause PC supporting the findings suggested by human studies.
The concordance with human and animal studies is buttressed by in vitro studies, although in vitro data interpretation is problematic.
In most instances, only significant effects are reported, and the concentrations of Cd are excessive, which would skew interpretation.
Previous reports suggest that oxidative stress, apoptotic changes, and DNA cross-linking and hypermethylation are involved in Cd-mediated carcinogenesis.
Undoubtedly, a significant amount of work is still needed to achieve a better understanding of the Cd involvement in pancreatic cancer which could facilitate prevention, diagnosis, and therapy of this fatal disease.
American Psychological Association (APA)
Buha, Aleksandra& Wallace, David& Matović, Vesna& Schweitzer, Amie& Oluic, Branislav& Micic, Dusan…[et al.]. 2017. Cadmium Exposure as a Putative Risk Factor for the Development of Pancreatic Cancer: Three Different Lines of Evidence. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1134395
Modern Language Association (MLA)
Buha, Aleksandra…[et al.]. Cadmium Exposure as a Putative Risk Factor for the Development of Pancreatic Cancer: Three Different Lines of Evidence. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1134395
American Medical Association (AMA)
Buha, Aleksandra& Wallace, David& Matović, Vesna& Schweitzer, Amie& Oluic, Branislav& Micic, Dusan…[et al.]. Cadmium Exposure as a Putative Risk Factor for the Development of Pancreatic Cancer: Three Different Lines of Evidence. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1134395
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134395