Association between the MMP-1-1607 1G2G Polymorphism and Osteoarthritis Risk: A Systematic Review and Meta-Analysis
المؤلفون المشاركون
Liu, Jiankun
Wang, Guangye
Peng, Zhan
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-27
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Background.
Osteoarthritis (OA) is a common disease characterized by articular cartilage degeneration and secondary hyperosteogenesis.
Genetic factors are associated with the occurrence of OA.
While several studies have shown that the matrix metalloproteinase-1- (MMP-1-) 1607 1G/2G (rs1799750) polymorphism may be related to the occurrence and development of OA, there is inconsistency in the literature.
To better estimate the relationship between the MMP-1 gene polymorphism and OA, a comprehensive meta-analysis of relevant literature was carried out.
Results.
In total, seven studies comprising 1245 OA patients and 1230 controls were included in this meta-analysis.
The combined results revealed no significant association between the MMP-1-1607 1G/2G polymorphism and risk of OA in the five genetic models.
However, after Bonferroni correction, the results of subgroup analysis revealed a significant correlation between the MMP-1-1607 1G/2G polymorphism and OA susceptibility in the temporomandibular joint (TMJ) OA subgroup (allelic: 2G vs.
1G: OR=1.575, 95%CI=1.259–1.972, P<0.01; recessive: 2G2G vs.
1G1G+1G2G: OR=2.411, 95%CI=1.658–3.504, P<0.01; and homozygote: 2G2G vs.
1G1G: OR=2.313, 95%CI=1.341, 3.991, P=0.003), the younger subgroup (aged less than 60 years; allelic: 2G vs.
1G: OR=1.635, 95%CI=1.354, 1.974, P<0.01; dominant: 2G1G+2G2G vs.
1G1G: OR=1.622, 95%CI=1.158, 2.271, P=0.005; recessive: 2G2G vs.
1G1G+1G2G: OR=2.209, 95%CI=1.718, 2.840, P<0.01; and homozygote: 2G2G vs.
1G1G: OR=2.578, 95%CI=1.798, 3.696, P<0.01), the larger subgroup (N>300), and the hospital-based case-control study (HCC) subgroup.
The sensitivity analysis suggested that the results of the meta-analysis were stable and reliable.
Begg’s funnel plot and Egger’s test indicated that there was no publication bias in this study.
Conclusion.
Our meta-analysis indicated that although the MMP-1-1607 1G/2G polymorphism was not significantly associated with OA susceptibility among the whole sample, it played a key role in the etiology and development of TMJ OA and OA in people aged less than 60 years.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Jiankun& Wang, Guangye& Peng, Zhan. 2020. Association between the MMP-1-1607 1G2G Polymorphism and Osteoarthritis Risk: A Systematic Review and Meta-Analysis. BioMed Research International،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1134560
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Jiankun…[et al.]. Association between the MMP-1-1607 1G2G Polymorphism and Osteoarthritis Risk: A Systematic Review and Meta-Analysis. BioMed Research International No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1134560
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Jiankun& Wang, Guangye& Peng, Zhan. Association between the MMP-1-1607 1G2G Polymorphism and Osteoarthritis Risk: A Systematic Review and Meta-Analysis. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1134560
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1134560
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر