Association between the MMP-1-1607 1G2G Polymorphism and Osteoarthritis Risk: A Systematic Review and Meta-Analysis
Joint Authors
Liu, Jiankun
Wang, Guangye
Peng, Zhan
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-27
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Background.
Osteoarthritis (OA) is a common disease characterized by articular cartilage degeneration and secondary hyperosteogenesis.
Genetic factors are associated with the occurrence of OA.
While several studies have shown that the matrix metalloproteinase-1- (MMP-1-) 1607 1G/2G (rs1799750) polymorphism may be related to the occurrence and development of OA, there is inconsistency in the literature.
To better estimate the relationship between the MMP-1 gene polymorphism and OA, a comprehensive meta-analysis of relevant literature was carried out.
Results.
In total, seven studies comprising 1245 OA patients and 1230 controls were included in this meta-analysis.
The combined results revealed no significant association between the MMP-1-1607 1G/2G polymorphism and risk of OA in the five genetic models.
However, after Bonferroni correction, the results of subgroup analysis revealed a significant correlation between the MMP-1-1607 1G/2G polymorphism and OA susceptibility in the temporomandibular joint (TMJ) OA subgroup (allelic: 2G vs.
1G: OR=1.575, 95%CI=1.259–1.972, P<0.01; recessive: 2G2G vs.
1G1G+1G2G: OR=2.411, 95%CI=1.658–3.504, P<0.01; and homozygote: 2G2G vs.
1G1G: OR=2.313, 95%CI=1.341, 3.991, P=0.003), the younger subgroup (aged less than 60 years; allelic: 2G vs.
1G: OR=1.635, 95%CI=1.354, 1.974, P<0.01; dominant: 2G1G+2G2G vs.
1G1G: OR=1.622, 95%CI=1.158, 2.271, P=0.005; recessive: 2G2G vs.
1G1G+1G2G: OR=2.209, 95%CI=1.718, 2.840, P<0.01; and homozygote: 2G2G vs.
1G1G: OR=2.578, 95%CI=1.798, 3.696, P<0.01), the larger subgroup (N>300), and the hospital-based case-control study (HCC) subgroup.
The sensitivity analysis suggested that the results of the meta-analysis were stable and reliable.
Begg’s funnel plot and Egger’s test indicated that there was no publication bias in this study.
Conclusion.
Our meta-analysis indicated that although the MMP-1-1607 1G/2G polymorphism was not significantly associated with OA susceptibility among the whole sample, it played a key role in the etiology and development of TMJ OA and OA in people aged less than 60 years.
American Psychological Association (APA)
Liu, Jiankun& Wang, Guangye& Peng, Zhan. 2020. Association between the MMP-1-1607 1G2G Polymorphism and Osteoarthritis Risk: A Systematic Review and Meta-Analysis. BioMed Research International،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1134560
Modern Language Association (MLA)
Liu, Jiankun…[et al.]. Association between the MMP-1-1607 1G2G Polymorphism and Osteoarthritis Risk: A Systematic Review and Meta-Analysis. BioMed Research International No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1134560
American Medical Association (AMA)
Liu, Jiankun& Wang, Guangye& Peng, Zhan. Association between the MMP-1-1607 1G2G Polymorphism and Osteoarthritis Risk: A Systematic Review and Meta-Analysis. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1134560
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134560