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Gender Differences in the Progression of Experimental Chronic Kidney Disease Induced by Chronic Nitric Oxide Inhibition
المؤلفون المشاركون
Cavaglieri, Rita de Cássia
Noronha, Irene L.
Fanelli, Camilla
Dellê, Humberto
Dominguez, Wagner Vasques
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-10-18
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Chronic kidney disease (CKD) is considered a public health problem, assuming epidemic proportions worldwide.
In this context, the preponderance of CKD prevalence in male over age-matched female patients is of note.
In the present study, we investigated the impact of the gender on the development of experimental CKD induced by chronic nitric oxide (NO) inhibition in Wistar male and female rats through the administration of L-NAME.
CKD model induced by L-NAME is characterized by systemic vasoconstriction, resulting in severe hypertension, albuminuria, renal ischemia, glomerulosclerosis, interstitial expansion, and macrophage infiltration.
After 30 days of CKD induction, male NAME rats exhibited remarkable albuminuria, augmented cortical histological damage, interstitial inflammation, and fibrosis.
Age-matched female NAME rats showed significantly lower albuminuria, diminished glomerular ischemia, and glomerulosclerosis, as well as a significant reduction in the expression of α-smooth muscle actin renal interstitial Ang II+ cells.
Thus, the present study demonstrated that female rats submitted to the NAME model developed less severe CKD than males.
Female renoprotection could be promoted by both the estrogen anti-inflammatory activity and/or by the lack of testosterone, related to renin-angiotensin-aldosterone system hyperactivation and fibrogenesis.
However, the influence of sex hormones on the progression of CKD needs to be further investigated.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fanelli, Camilla& Dellê, Humberto& Cavaglieri, Rita de Cássia& Dominguez, Wagner Vasques& Noronha, Irene L.. 2017. Gender Differences in the Progression of Experimental Chronic Kidney Disease Induced by Chronic Nitric Oxide Inhibition. BioMed Research International،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1134593
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fanelli, Camilla…[et al.]. Gender Differences in the Progression of Experimental Chronic Kidney Disease Induced by Chronic Nitric Oxide Inhibition. BioMed Research International No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1134593
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fanelli, Camilla& Dellê, Humberto& Cavaglieri, Rita de Cássia& Dominguez, Wagner Vasques& Noronha, Irene L.. Gender Differences in the Progression of Experimental Chronic Kidney Disease Induced by Chronic Nitric Oxide Inhibition. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1134593
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1134593
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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