Gender Differences in the Progression of Experimental Chronic Kidney Disease Induced by Chronic Nitric Oxide Inhibition
Joint Authors
Cavaglieri, Rita de Cássia
Noronha, Irene L.
Fanelli, Camilla
Dellê, Humberto
Dominguez, Wagner Vasques
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-18
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Chronic kidney disease (CKD) is considered a public health problem, assuming epidemic proportions worldwide.
In this context, the preponderance of CKD prevalence in male over age-matched female patients is of note.
In the present study, we investigated the impact of the gender on the development of experimental CKD induced by chronic nitric oxide (NO) inhibition in Wistar male and female rats through the administration of L-NAME.
CKD model induced by L-NAME is characterized by systemic vasoconstriction, resulting in severe hypertension, albuminuria, renal ischemia, glomerulosclerosis, interstitial expansion, and macrophage infiltration.
After 30 days of CKD induction, male NAME rats exhibited remarkable albuminuria, augmented cortical histological damage, interstitial inflammation, and fibrosis.
Age-matched female NAME rats showed significantly lower albuminuria, diminished glomerular ischemia, and glomerulosclerosis, as well as a significant reduction in the expression of α-smooth muscle actin renal interstitial Ang II+ cells.
Thus, the present study demonstrated that female rats submitted to the NAME model developed less severe CKD than males.
Female renoprotection could be promoted by both the estrogen anti-inflammatory activity and/or by the lack of testosterone, related to renin-angiotensin-aldosterone system hyperactivation and fibrogenesis.
However, the influence of sex hormones on the progression of CKD needs to be further investigated.
American Psychological Association (APA)
Fanelli, Camilla& Dellê, Humberto& Cavaglieri, Rita de Cássia& Dominguez, Wagner Vasques& Noronha, Irene L.. 2017. Gender Differences in the Progression of Experimental Chronic Kidney Disease Induced by Chronic Nitric Oxide Inhibition. BioMed Research International،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1134593
Modern Language Association (MLA)
Fanelli, Camilla…[et al.]. Gender Differences in the Progression of Experimental Chronic Kidney Disease Induced by Chronic Nitric Oxide Inhibition. BioMed Research International No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1134593
American Medical Association (AMA)
Fanelli, Camilla& Dellê, Humberto& Cavaglieri, Rita de Cássia& Dominguez, Wagner Vasques& Noronha, Irene L.. Gender Differences in the Progression of Experimental Chronic Kidney Disease Induced by Chronic Nitric Oxide Inhibition. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1134593
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134593