Establishment and Characteristic Analysis of a Dog Model for Autologous Homologous Cranioplasty
المؤلفون المشاركون
Zhu, Wenyu
Wu, Jie
Zhao, Haifeng
Wang, Weihua
Lu, Lichun
Yan, Ke
Yin, Yin
Huang, Qiang
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-27
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Objective.
The aim of this study is to establish a large animal (dog) model that can be referred clinically for autologous homologous cranioplasty.
Methods.
Our large skull defect dog model was established by emulating the decompressive craniectomy with 22 adult beagle dogs.
The autologous bones were taken out from the dogs and divided into two groups, the freeze-drying (FD) group and the single freezing (SF) group.
They were then stored in the bone bank at -20°C after being irradiated with 25 KGy.
Three months later, the bones were reimplanted.
After operation, we closely watch the experimental objects for four more months examining the infection and survival of the bone graft.
Results.
Through macroscopic observation, it was found that, among 44 cranial flaps (bilateral) from the rest of the 22 dogs, grade A cranial flaps accounted for 86.4% (19/22) in the SF group and only 31.8% (7/22) in the FD group.
Although osteogenic osteoclast, Harvard tube, neovascularization, and angiogenic factors were found through the pathological results, including an electron microscope and calmodulin tracer, it could be verified by using X-CT and micro-CT that early bone resorption could be still found even in grade A bone flap.
Conclusion.
By using the common clinical method to preserve the cranial flaps, we established an experimental dog model of autologous cranioplasty for a large area of cranial defect.
It was proved that this model could reproduce the infections and bone resorption which typically happened in clinical autologous homologous cranioplasty.
As a conclusion, the established model can be used as an effective experimental tool for further research to improve the success rate of autologous homologous cranioplasty.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhu, Wenyu& Wu, Jie& Zhao, Haifeng& Wang, Weihua& Lu, Lichun& Yan, Ke…[et al.]. 2020. Establishment and Characteristic Analysis of a Dog Model for Autologous Homologous Cranioplasty. BioMed Research International،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1134706
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhu, Wenyu…[et al.]. Establishment and Characteristic Analysis of a Dog Model for Autologous Homologous Cranioplasty. BioMed Research International No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1134706
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhu, Wenyu& Wu, Jie& Zhao, Haifeng& Wang, Weihua& Lu, Lichun& Yan, Ke…[et al.]. Establishment and Characteristic Analysis of a Dog Model for Autologous Homologous Cranioplasty. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1134706
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1134706
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر