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Establishment and Characteristic Analysis of a Dog Model for Autologous Homologous Cranioplasty
Joint Authors
Zhu, Wenyu
Wu, Jie
Zhao, Haifeng
Wang, Weihua
Lu, Lichun
Yan, Ke
Yin, Yin
Huang, Qiang
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-27
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Objective.
The aim of this study is to establish a large animal (dog) model that can be referred clinically for autologous homologous cranioplasty.
Methods.
Our large skull defect dog model was established by emulating the decompressive craniectomy with 22 adult beagle dogs.
The autologous bones were taken out from the dogs and divided into two groups, the freeze-drying (FD) group and the single freezing (SF) group.
They were then stored in the bone bank at -20°C after being irradiated with 25 KGy.
Three months later, the bones were reimplanted.
After operation, we closely watch the experimental objects for four more months examining the infection and survival of the bone graft.
Results.
Through macroscopic observation, it was found that, among 44 cranial flaps (bilateral) from the rest of the 22 dogs, grade A cranial flaps accounted for 86.4% (19/22) in the SF group and only 31.8% (7/22) in the FD group.
Although osteogenic osteoclast, Harvard tube, neovascularization, and angiogenic factors were found through the pathological results, including an electron microscope and calmodulin tracer, it could be verified by using X-CT and micro-CT that early bone resorption could be still found even in grade A bone flap.
Conclusion.
By using the common clinical method to preserve the cranial flaps, we established an experimental dog model of autologous cranioplasty for a large area of cranial defect.
It was proved that this model could reproduce the infections and bone resorption which typically happened in clinical autologous homologous cranioplasty.
As a conclusion, the established model can be used as an effective experimental tool for further research to improve the success rate of autologous homologous cranioplasty.
American Psychological Association (APA)
Zhu, Wenyu& Wu, Jie& Zhao, Haifeng& Wang, Weihua& Lu, Lichun& Yan, Ke…[et al.]. 2020. Establishment and Characteristic Analysis of a Dog Model for Autologous Homologous Cranioplasty. BioMed Research International،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1134706
Modern Language Association (MLA)
Zhu, Wenyu…[et al.]. Establishment and Characteristic Analysis of a Dog Model for Autologous Homologous Cranioplasty. BioMed Research International No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1134706
American Medical Association (AMA)
Zhu, Wenyu& Wu, Jie& Zhao, Haifeng& Wang, Weihua& Lu, Lichun& Yan, Ke…[et al.]. Establishment and Characteristic Analysis of a Dog Model for Autologous Homologous Cranioplasty. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1134706
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134706