The Correlation between PSCA Expression and Neuroendocrine Differentiation in Prostate Cancer
المؤلفون المشاركون
Xiang, Qian
Zhu, Zhiguo
Luo, Lianmin
Wang, Jiamin
Liu, Yangzhou
Deng, Yihan
Zhou, Mingda
Zhao, Zhigang
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-09-24
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The prostate stem cell antigen (PSCA), as a predominantly prostate-specific marker, is overexpressed in most prostate cancer specimens, is positively correlated with prostate cancer androgen independence, and has the potential to be treated with castration-resistant prostate cancer (CRPC) as a gene therapy target.
Using the typical androgen deprivation therapy, most tumors will progress to CRPC, as well as develop into neuroendocrine prostate cancer (NEPC) characterized by the expression of neuroendocrine markers such as enolase 2 (NSE).
Our study was aimed at investigating the expressions of PSCA and NSE and the relationship between the two markers, as well as the correlation between the PSCA and NSE expressions and the clinicopathological parameters in prostate cancer specimens from 118 patients by using immunohistochemistry.
Our results demonstrated that the PSCA and NSE protein expressions did not correlate with the prostate cancer patients’ age or the hormone therapy but showed a significant correlation with the pathological tumor stage of prostate cancer, the Gleason score, and the presence of metastasis.
There is a positive association between PSCA and NSE but a negative one between the prostate-specific antigen (PSA) and PSCA or between PSA and NSE.
High PSCA and NSE expressions correlated with a poor prognosis in prostate cancer patients.
PSCA may play an important role in the progression of neuroendocrine prostate cancer (NEPC).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xiang, Qian& Zhu, Zhiguo& Luo, Lianmin& Wang, Jiamin& Liu, Yangzhou& Deng, Yihan…[et al.]. 2020. The Correlation between PSCA Expression and Neuroendocrine Differentiation in Prostate Cancer. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1134747
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xiang, Qian…[et al.]. The Correlation between PSCA Expression and Neuroendocrine Differentiation in Prostate Cancer. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1134747
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xiang, Qian& Zhu, Zhiguo& Luo, Lianmin& Wang, Jiamin& Liu, Yangzhou& Deng, Yihan…[et al.]. The Correlation between PSCA Expression and Neuroendocrine Differentiation in Prostate Cancer. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1134747
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1134747
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر