![](/images/graphics-bg.png)
The Correlation between PSCA Expression and Neuroendocrine Differentiation in Prostate Cancer
Joint Authors
Xiang, Qian
Zhu, Zhiguo
Luo, Lianmin
Wang, Jiamin
Liu, Yangzhou
Deng, Yihan
Zhou, Mingda
Zhao, Zhigang
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The prostate stem cell antigen (PSCA), as a predominantly prostate-specific marker, is overexpressed in most prostate cancer specimens, is positively correlated with prostate cancer androgen independence, and has the potential to be treated with castration-resistant prostate cancer (CRPC) as a gene therapy target.
Using the typical androgen deprivation therapy, most tumors will progress to CRPC, as well as develop into neuroendocrine prostate cancer (NEPC) characterized by the expression of neuroendocrine markers such as enolase 2 (NSE).
Our study was aimed at investigating the expressions of PSCA and NSE and the relationship between the two markers, as well as the correlation between the PSCA and NSE expressions and the clinicopathological parameters in prostate cancer specimens from 118 patients by using immunohistochemistry.
Our results demonstrated that the PSCA and NSE protein expressions did not correlate with the prostate cancer patients’ age or the hormone therapy but showed a significant correlation with the pathological tumor stage of prostate cancer, the Gleason score, and the presence of metastasis.
There is a positive association between PSCA and NSE but a negative one between the prostate-specific antigen (PSA) and PSCA or between PSA and NSE.
High PSCA and NSE expressions correlated with a poor prognosis in prostate cancer patients.
PSCA may play an important role in the progression of neuroendocrine prostate cancer (NEPC).
American Psychological Association (APA)
Xiang, Qian& Zhu, Zhiguo& Luo, Lianmin& Wang, Jiamin& Liu, Yangzhou& Deng, Yihan…[et al.]. 2020. The Correlation between PSCA Expression and Neuroendocrine Differentiation in Prostate Cancer. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1134747
Modern Language Association (MLA)
Xiang, Qian…[et al.]. The Correlation between PSCA Expression and Neuroendocrine Differentiation in Prostate Cancer. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1134747
American Medical Association (AMA)
Xiang, Qian& Zhu, Zhiguo& Luo, Lianmin& Wang, Jiamin& Liu, Yangzhou& Deng, Yihan…[et al.]. The Correlation between PSCA Expression and Neuroendocrine Differentiation in Prostate Cancer. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1134747
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134747