Lack of Clinical Relevance of ANA and ASMA Positivity in Patients with Liver Transplantation without a History of Autoimmune Diseases
المؤلفون المشاركون
Zingone, F.
Santonicola, Antonella
Pellegrini, Lucienne
Parrilli, Gianpaolo
Cinquanta, Luigi
Caputo, Cesare
Ciacci, C.
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-27
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The relevance of isolated autoimmunity elevation in orthotopic liver transplantation (OLT) patients is unknown.
Our aim was to analyse how serum autoantibodies change in time and to evaluate their clinical relevance in OLT patients.
Patients were invited to provide samples to evaluate ANA, AMA, ASMA, and LKM at the time of enrolment (T0), after 6 months (T6), and after 12 months (T12).
We included 114 patients in the study (76% males, median age 62.5 years), finding isolated elevation of at least one serum antibody in up to 80% of them.
We described fluctuating positive autoantibodies in the one year of observation, with only 45.6% of patients positive for ANA and less than 2% positive for ASMA, at all three times.
Isolated elevation of tissue antibodies was not related to gender, age, HCC at transplant, early rejection, cause of transplantation, immunotherapy taken, and age at the time of the study.
We did not detect a higher prevalence of positive autoimmunity in patients with signs of liver injury.
ANA and ASMA evaluation in patients with liver transplantation and no history of autoimmune disease has no clinical relevance, since it varies in time and is not related to any risk factors or liver injury.
Routine autoimmunity evaluation should be avoided.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pellegrini, Lucienne& Parrilli, Gianpaolo& Santonicola, Antonella& Cinquanta, Luigi& Caputo, Cesare& Ciacci, C.…[et al.]. 2017. Lack of Clinical Relevance of ANA and ASMA Positivity in Patients with Liver Transplantation without a History of Autoimmune Diseases. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1134770
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pellegrini, Lucienne…[et al.]. Lack of Clinical Relevance of ANA and ASMA Positivity in Patients with Liver Transplantation without a History of Autoimmune Diseases. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1134770
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pellegrini, Lucienne& Parrilli, Gianpaolo& Santonicola, Antonella& Cinquanta, Luigi& Caputo, Cesare& Ciacci, C.…[et al.]. Lack of Clinical Relevance of ANA and ASMA Positivity in Patients with Liver Transplantation without a History of Autoimmune Diseases. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1134770
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1134770
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر