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Lack of Clinical Relevance of ANA and ASMA Positivity in Patients with Liver Transplantation without a History of Autoimmune Diseases
Joint Authors
Zingone, F.
Santonicola, Antonella
Pellegrini, Lucienne
Parrilli, Gianpaolo
Cinquanta, Luigi
Caputo, Cesare
Ciacci, C.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The relevance of isolated autoimmunity elevation in orthotopic liver transplantation (OLT) patients is unknown.
Our aim was to analyse how serum autoantibodies change in time and to evaluate their clinical relevance in OLT patients.
Patients were invited to provide samples to evaluate ANA, AMA, ASMA, and LKM at the time of enrolment (T0), after 6 months (T6), and after 12 months (T12).
We included 114 patients in the study (76% males, median age 62.5 years), finding isolated elevation of at least one serum antibody in up to 80% of them.
We described fluctuating positive autoantibodies in the one year of observation, with only 45.6% of patients positive for ANA and less than 2% positive for ASMA, at all three times.
Isolated elevation of tissue antibodies was not related to gender, age, HCC at transplant, early rejection, cause of transplantation, immunotherapy taken, and age at the time of the study.
We did not detect a higher prevalence of positive autoimmunity in patients with signs of liver injury.
ANA and ASMA evaluation in patients with liver transplantation and no history of autoimmune disease has no clinical relevance, since it varies in time and is not related to any risk factors or liver injury.
Routine autoimmunity evaluation should be avoided.
American Psychological Association (APA)
Pellegrini, Lucienne& Parrilli, Gianpaolo& Santonicola, Antonella& Cinquanta, Luigi& Caputo, Cesare& Ciacci, C.…[et al.]. 2017. Lack of Clinical Relevance of ANA and ASMA Positivity in Patients with Liver Transplantation without a History of Autoimmune Diseases. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1134770
Modern Language Association (MLA)
Pellegrini, Lucienne…[et al.]. Lack of Clinical Relevance of ANA and ASMA Positivity in Patients with Liver Transplantation without a History of Autoimmune Diseases. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1134770
American Medical Association (AMA)
Pellegrini, Lucienne& Parrilli, Gianpaolo& Santonicola, Antonella& Cinquanta, Luigi& Caputo, Cesare& Ciacci, C.…[et al.]. Lack of Clinical Relevance of ANA and ASMA Positivity in Patients with Liver Transplantation without a History of Autoimmune Diseases. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1134770
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134770