Pharmacokinetic and Pharmacodynamic Evaluation of Marbofloxacin in Pig against Korean Local Isolates of Actinobacillus pleuropneumoniae
المؤلفون المشاركون
Park, Hae-chul
Jeong, Kyunghun
Jang, Yang ho
Kim, Dae Gyun
Kang, JeongWoo
Lee, Kwang-jick
Hossain, Md. Akil
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-04-06
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
The pharmacokinetics of marbofloxacin in pigs after intravenous (i.v.), intramuscular (i.m.), and peroral (p.o.) administration and pharmacokinetic/pharmacodynamic indices of this drug against Korean local isolates of Actinobacillus pleuropneumoniae were determined in this study.
Marbofloxacin (2.50 mg/kg of body weight) was administered, and blood samples were collected with designated time intervals.
Plasma-extracted marbofloxacin was injected into the LC-MS/MS system.
The in vitro and ex vivo antibacterial activities of marbofloxacin were evaluated against 20 isolates of A.
pleuropneumoniae.
The mean peak plasma concentrations (Cmax) after i.v., i.m., and p.o administration were 2.60±0.10, 2.59±0.12, and 2.34±0.12 µg/mL at 0.25±0.00, 0.44±0.10, and 1.58±0.40 h, respectively.
The area under the plasma concentration-time curves (AUC0–24) and elimination half-lives were 24.80±0.90, 25.80±1.40, and 23.40±5.00 h·μg/mL and 8.60±0.30, 12.80±1.10, and 8.60±0.00 h, for i.v., i.m., and p.o.
administration, correspondingly.
The AUC0–24/MICs of marbofloxacin after i.v., i.m., and p.o.
administration were 253.86±179.91, 264.1±187.16, and 239.53±169.75 h, respectively.
The Cmax/MIC values were 26.58±18.84, 26.48±18.77, and 23.94±16.97, and T>MICs were 42.80±1.01, 36.40±1.24, and 38.60±1.18 h, after i.v., i.m., and p.o.
administration, respectively.
Thus, marbofloxacin dosage of 2.50 mg/kg of body weight by i.v., i.m., and p.o.
administration with 24 h dosing interval will provide effective treatment for the infection of pig by A.
pleuropneumonia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hossain, Md. Akil& Park, Hae-chul& Jeong, Kyunghun& Jang, Yang ho& Kim, Dae Gyun& Kang, JeongWoo…[et al.]. 2017. Pharmacokinetic and Pharmacodynamic Evaluation of Marbofloxacin in Pig against Korean Local Isolates of Actinobacillus pleuropneumoniae. BioMed Research International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1134778
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hossain, Md. Akil…[et al.]. Pharmacokinetic and Pharmacodynamic Evaluation of Marbofloxacin in Pig against Korean Local Isolates of Actinobacillus pleuropneumoniae. BioMed Research International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1134778
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hossain, Md. Akil& Park, Hae-chul& Jeong, Kyunghun& Jang, Yang ho& Kim, Dae Gyun& Kang, JeongWoo…[et al.]. Pharmacokinetic and Pharmacodynamic Evaluation of Marbofloxacin in Pig against Korean Local Isolates of Actinobacillus pleuropneumoniae. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1134778
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1134778
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر