Pharmacokinetic and Pharmacodynamic Evaluation of Marbofloxacin in Pig against Korean Local Isolates of Actinobacillus pleuropneumoniae
Joint Authors
Park, Hae-chul
Jeong, Kyunghun
Jang, Yang ho
Kim, Dae Gyun
Kang, JeongWoo
Lee, Kwang-jick
Hossain, Md. Akil
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-06
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The pharmacokinetics of marbofloxacin in pigs after intravenous (i.v.), intramuscular (i.m.), and peroral (p.o.) administration and pharmacokinetic/pharmacodynamic indices of this drug against Korean local isolates of Actinobacillus pleuropneumoniae were determined in this study.
Marbofloxacin (2.50 mg/kg of body weight) was administered, and blood samples were collected with designated time intervals.
Plasma-extracted marbofloxacin was injected into the LC-MS/MS system.
The in vitro and ex vivo antibacterial activities of marbofloxacin were evaluated against 20 isolates of A.
pleuropneumoniae.
The mean peak plasma concentrations (Cmax) after i.v., i.m., and p.o administration were 2.60±0.10, 2.59±0.12, and 2.34±0.12 µg/mL at 0.25±0.00, 0.44±0.10, and 1.58±0.40 h, respectively.
The area under the plasma concentration-time curves (AUC0–24) and elimination half-lives were 24.80±0.90, 25.80±1.40, and 23.40±5.00 h·μg/mL and 8.60±0.30, 12.80±1.10, and 8.60±0.00 h, for i.v., i.m., and p.o.
administration, correspondingly.
The AUC0–24/MICs of marbofloxacin after i.v., i.m., and p.o.
administration were 253.86±179.91, 264.1±187.16, and 239.53±169.75 h, respectively.
The Cmax/MIC values were 26.58±18.84, 26.48±18.77, and 23.94±16.97, and T>MICs were 42.80±1.01, 36.40±1.24, and 38.60±1.18 h, after i.v., i.m., and p.o.
administration, respectively.
Thus, marbofloxacin dosage of 2.50 mg/kg of body weight by i.v., i.m., and p.o.
administration with 24 h dosing interval will provide effective treatment for the infection of pig by A.
pleuropneumonia.
American Psychological Association (APA)
Hossain, Md. Akil& Park, Hae-chul& Jeong, Kyunghun& Jang, Yang ho& Kim, Dae Gyun& Kang, JeongWoo…[et al.]. 2017. Pharmacokinetic and Pharmacodynamic Evaluation of Marbofloxacin in Pig against Korean Local Isolates of Actinobacillus pleuropneumoniae. BioMed Research International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1134778
Modern Language Association (MLA)
Hossain, Md. Akil…[et al.]. Pharmacokinetic and Pharmacodynamic Evaluation of Marbofloxacin in Pig against Korean Local Isolates of Actinobacillus pleuropneumoniae. BioMed Research International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1134778
American Medical Association (AMA)
Hossain, Md. Akil& Park, Hae-chul& Jeong, Kyunghun& Jang, Yang ho& Kim, Dae Gyun& Kang, JeongWoo…[et al.]. Pharmacokinetic and Pharmacodynamic Evaluation of Marbofloxacin in Pig against Korean Local Isolates of Actinobacillus pleuropneumoniae. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1134778
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134778