Interaction of MRE11 and Clinicopathologic Characteristics in Recurrence of Breast Cancer: Individual and Cumulated Receiver Operating Characteristic Analyses
المؤلفون المشاركون
Chang, Hsueh-Wei
Chuang, Li-Yeh
Lee, Yi-Chen
Moi, Sin-Hua
Hou, Ming-Feng
Yuan, Shyng Shiou
Yang, Cheng-Hong
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-04
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The interaction between the meiotic recombination 11 homolog A (MRE11) oncoprotein and breast cancer recurrence status remains unclear.
The aim of this study was to assess the interaction between MRE11 and clinicopathologic variables in breast cancer.
A dataset for 254 subjects with breast cancer (220 nonrecurrent and 34 recurrent) was used in individual and cumulated receiver operating characteristic (ROC) analyses of MRE11 and 12 clinicopathologic variables for predicting breast cancer recurrence.
In individual ROC analysis, the area under curve (AUC) for each predictor of breast cancer recurrence was smaller than 0.7.
In cumulated ROC analysis, however, the AUC value for each predictor improved.
Ten relevant variables in breast cancer recurrence were used to find the optimal prognostic indicators.
The presence of any six of the following ten variables had a high (79%) sensitivity and a high (70%) specificity for predicting breast cancer recurrence: tumor size ≥ 2.4 cm, tumor stage II/III, therapy other than hormone therapy, age ≥ 52 years, MRE11 positive cells > 50%, body mass index ≥ 24, lymph node metastasis, positivity for progesterone receptor, positivity for epidermal growth factor receptor, and negativity for estrogen receptor.
In conclusion, this study revealed that these 10 clinicopathologic variables are the minimum discriminators needed for optimal discriminant effectiveness in predicting breast cancer recurrence.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Cheng-Hong& Moi, Sin-Hua& Chuang, Li-Yeh& Yuan, Shyng Shiou& Hou, Ming-Feng& Lee, Yi-Chen…[et al.]. 2017. Interaction of MRE11 and Clinicopathologic Characteristics in Recurrence of Breast Cancer: Individual and Cumulated Receiver Operating Characteristic Analyses. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1134907
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Cheng-Hong…[et al.]. Interaction of MRE11 and Clinicopathologic Characteristics in Recurrence of Breast Cancer: Individual and Cumulated Receiver Operating Characteristic Analyses. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1134907
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Cheng-Hong& Moi, Sin-Hua& Chuang, Li-Yeh& Yuan, Shyng Shiou& Hou, Ming-Feng& Lee, Yi-Chen…[et al.]. Interaction of MRE11 and Clinicopathologic Characteristics in Recurrence of Breast Cancer: Individual and Cumulated Receiver Operating Characteristic Analyses. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1134907
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1134907
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر